{
  "id": 8399,
  "label": "small cell sarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006974",
  "properties": {
    "xrefs": [
      "DOID:3098",
      "EFO:1001184",
      "ICDO:8803/3",
      "MEDGEN:60201",
      "MESH:D018228",
      "NCIT:C3746",
      "UMLS:C0206652"
    ],
    "synonyms": [
      "small cell sarcoma",
      "small cell sarcomas"
    ],
    "definition": "A sarcoma characterized by the presence of small round or elongated malignant cells with a small amount of cytoplasm."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 6816,
      "label": "sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1115",
          "EFO:0000691",
          "ICD9:171",
          "ICD9:171.0",
          "ICD9:171.2",
          "ICD9:171.3",
          "ICD9:171.4",
          "ICD9:171.5",
          "ICD9:171.6",
          "ICD9:171.7",
          "ICD9:171.8",
          "ICD9:171.9",
          "ICDO:8800/3",
          "MEDGEN:224714",
          "MESH:D012509",
          "NCIT:C9118",
          "SCTID:424413001",
          "UMLS:C1261473"
        ],
        "synonyms": [
          "mesenchymal tumor, malignant",
          "sarcoma",
          "sarcoma of soft tissue and bone",
          "sarcoma of the soft tissue and bone",
          "sarcoma, malignant",
          "tumor of soft tissue and skeleton",
          "tumour of soft tissue and skeleton"
        ],
        "definition": "A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005089"
    }
  ],
  "children": [
    {
      "id": 4681,
      "label": "small cell osteogenic sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4262,
        8399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3377",
          "GARD:0023197",
          "ICDO:9185/3",
          "MEDGEN:83532",
          "NCIT:C4023",
          "ONCOTREE:SCOS",
          "UMLS:C0279622"
        ],
        "synonyms": [
          "small cell osteosarcoma",
          "SCOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An osteosarcoma usually arising from the metaphysis of long bones. It is characterized by the presence of small cells and osteoid production. The prognosis is usually unfavorable."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002630"
    },
    {
      "id": 8296,
      "label": "mesenchymal chondrosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8399,
        10235
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4545",
          "EFO:1001041",
          "GARD:0024490",
          "ICDO:9240/3",
          "MEDGEN:104904",
          "MESH:D018211",
          "MedDRA:10027389",
          "NCIT:C3737",
          "ONCOTREE:MCHS",
          "UMLS:C0206637"
        ],
        "synonyms": [
          "mesenchymal chondrosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A morphologic variant of chondrosarcoma arising from bone and soft tissue. It is characterized by the presence of malignant small round cells, biphasic growth pattern, and well differentiated hyaline cartilage. Clinical presentation includes pain and swelling. The clinical course is aggressive, with local recurrences and distant metastases."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006853"
    },
    {
      "id": 19207,
      "label": "desmoplastic small round cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8399,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6785",
          "EFO:1000895",
          "GARD:0006265",
          "HGNC:12796",
          "ICDO:8806/3",
          "MEDGEN:83833",
          "MESH:D058405",
          "MedDRA:10064581",
          "MedDRA:10064587",
          "NANDO:2200059",
          "NCIT:C8300",
          "ONCOTREE:DSRCT",
          "Orphanet:83469",
          "UMLS:C0281508"
        ],
        "synonyms": [
          "DSRCT",
          "Desmoplas. small round cell tumor",
          "Desmoplas. small round cell tumour",
          "Desmoplastic small round cell tumor",
          "Desmoplastic small round cell tumour",
          "Desmoplastic small round-cell neoplasm",
          "Desmoplastic small round-cell tumor",
          "Desmoplastic small round-cell tumour",
          "Polyphenotypic small round cell tumor",
          "Polyphenotypic small round cell tumour",
          "desmoplastic small round cell tumor",
          "desmoplastic small-round-cell tumor",
          "desmoplastic small-round-cell tumour"
        ],
        "definition": "Desmoplastic small round cell tumor (DSRCT) is an aggressive soft tissue cancer that typically arises in serous lined surfaces of the abdominal or pelvic peritoneum, and spreads to the omentum, lymph nodes and hematogenously disseminates especially to the liver. Extraserous primary location has been reported in exceptional cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019373"
    },
    {
      "id": 25251,
      "label": "EWSR1-negative small round cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081249",
          "MEDGEN:1714743",
          "NCIT:C165671",
          "UMLS:C5237359"
        ],
        "definition": "A small cell sarcoma that is characterized by the absence of EWSR1 rearrangement and the presence of small round malignant cells with a small amount of cytoplasm."
      },
      "child_count": 1,
      "reference_id": "MONDO:0858921"
    },
    {
      "id": 25842,
      "label": "sarcoma with BCOR genetic alterations",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081402",
          "MEDGEN:1791498",
          "NCIT:C178465",
          "UMLS:C5555057"
        ],
        "definition": "A small cell sarcoma that is characterized by the presence of small round or elongated malignant cells with a small amount of cytoplasm and the presence of BCOR genetic alterations."
      },
      "child_count": 3,
      "reference_id": "MONDO:0958159"
    },
    {
      "id": 25843,
      "label": "round cell sarcoma with EWSR1-non-ETS fusion",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081406",
          "MEDGEN:1790023",
          "NCIT:C178459",
          "UMLS:C4727985"
        ],
        "definition": "A small cell sarcoma that is characterized by the presence of EWSR1 or FUS fusions involving partners unrelated to the ETS gene family."
      },
      "child_count": 4,
      "reference_id": "MONDO:0958160"
    }
  ],
  "roots": [
    {
      "id": 6816,
      "label": "sarcoma"
    }
  ]
}