{
  "id": 8411,
  "label": "subvalvular aortic stenosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006987",
  "properties": {
    "xrefs": [
      "DOID:5805",
      "EFO:1001199",
      "GARD:0005052",
      "MEDGEN:90950",
      "MESH:D001020",
      "MedDRA:10042431",
      "NANDO:2100093",
      "NANDO:2200277",
      "NCIT:C85172",
      "SCTID:204368006",
      "UMLS:C0340375"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "An aortic stenosis caused by fibromuscular stenosis or hypertrophic cardiomyopathy. It may be associated with congenital heart defects."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 23105,
      "label": "aortic valve stenosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5678,
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1712",
          "HP:0001650",
          "ICD10CM:I06.0",
          "ICD9:395.0",
          "MEDGEN:1621",
          "MESH:D001024",
          "NANDO:2200306",
          "NCIT:C50462",
          "SCTID:60573004",
          "SCTID:72011007",
          "UMLS:C0003507",
          "icd11.foundation:956813047"
        ],
        "synonyms": [
          "AS",
          "aortic stenosis",
          "rheumatic aortic stenosis",
          "rheumatic aortic valve stenosis",
          "stenosed aortic valve",
          "valvular aortic stenosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Aortic valve stenosis (AVS) is a condition characterized by narrowing of the heart's aortic valve opening. This narrowing prevents the valve from opening fully, which obstructs blood flow from the heart into the aorta, and onward to the rest of the body. AVS can range from mild to severe. Signs and symptoms typically develop when the narrowing of the opening is severe and may include chest pain (angina) or tightness; shortness of breath or fatigue (especially during exertion); feeling faint or fainting; heart palpitations; and heart murmur. Individuals with less severe congenital AVS (present at birth) may not develop symptoms until adulthood. Individuals with severe cases may faint without warning. AVS can have several causes including abnormal development before birth (such as having 1 or 2 valve leaflets instead of 3); calcium build-up on the valve in adulthood; and rheumatic fever."
      },
      "child_count": 8,
      "reference_id": "MONDO:0042981"
    }
  ],
  "children": [
    {
      "id": 8186,
      "label": "discrete subaortic stenosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5804",
          "GARD:0024463",
          "MEDGEN:3867",
          "MESH:D021922",
          "UMLS:C0012628"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A type of constriction that is caused by the presence of a fibrous ring (discrete type) below the aortic valve, anywhere between the aortic valve and the mitral valve. It is characterized by restricted outflow from the left ventricle into the aorta."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006729"
    }
  ],
  "roots": [
    {
      "id": 23105,
      "label": "aortic valve stenosis"
    }
  ]
}