{
  "id": 8426,
  "label": "type III hypersensitivity disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007004",
  "properties": {
    "xrefs": [
      "DOID:1557",
      "EFO:1001222",
      "MEDGEN:7021",
      "MESH:D007105",
      "MedDRA:10045265",
      "NCIT:C114346",
      "UMLS:C0020951"
    ],
    "synonyms": [
      "disorder of type III hypersensitivity",
      "type 3 hypersensitivity reaction",
      "type III hypersensitivity",
      "type III hypersensitivity reaction",
      "hypersensitivity reaction type III disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides serum sickness and the arthus reaction, evidence supports a pathogenic role for immune complexes in many other immune system diseases including glomerulonephritis, systemic lupus erythematosus (lupus erythematosus, systemic) and polyarteritis nodosa."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060056",
          "EFO:1002003",
          "MEDGEN:759636",
          "NCIT:C3114",
          "SCTID:473010000",
          "UMLS:C3532523"
        ],
        "synonyms": [
          "allergic reaction",
          "sensitive",
          "sensitivity",
          "hypersensitive",
          "hypersensitivity",
          "hypersensitivity reaction"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000605"
    },
    {
      "id": 8586,
      "label": "autoimmune disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:417",
          "EFO:0005809",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:720",
          "MEDGEN:2135",
          "MESH:D001327",
          "NCIT:C2889",
          "OBI:1110054",
          "OMIM:109100",
          "SCTID:85828009",
          "UMLS:C0004364"
        ],
        "synonyms": [
          "autoimmune disease",
          "autoimmune disease or disorder",
          "autoimmune disorder",
          "disease, autoimmune",
          "autoimmune hypersensitivity disease",
          "hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis)."
      },
      "child_count": 47,
      "reference_id": "MONDO:0007179"
    }
  ],
  "children": [
    {
      "id": 8131,
      "label": "arthus reaction",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8426
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1556",
          "EFO:1000821",
          "ICD9:708.8",
          "ICD9:995.21",
          "MEDGEN:2458",
          "MESH:D001183",
          "MedDRA:10003420",
          "NCIT:C34400",
          "SCTID:402413008",
          "UMLS:C0003907"
        ],
        "synonyms": [
          "arthus phenomenon",
          "arthus reaction",
          "arthus reaction (function)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A localized vasculitis resulting from deposition of antibody-antigen complexes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006660"
    },
    {
      "id": 23250,
      "label": "serum sickness",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4539,
        8426
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:11390",
          "MESH:D012713",
          "NCIT:C79718",
          "SCTID:72284000",
          "UMLS:C0036830",
          "icd11.foundation:715261250"
        ],
        "synonyms": [
          "serum sickness",
          "transfusion reaction due to serum protein reaction",
          "Sicknesses, serum",
          "intoxication by serum",
          "protein sickness",
          "serum Sicknesses",
          "serum reaction",
          "sickness, serum"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis B) may also cause serum sickness-like reaction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043789"
    }
  ],
  "roots": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease"
    },
    {
      "id": 8586,
      "label": "autoimmune disease"
    }
  ]
}