{
  "id": 8479,
  "label": "spermatogenic failure 6",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007060",
  "properties": {
    "xrefs": [
      "DOID:0070167",
      "GARD:0015032",
      "MEDGEN:900925",
      "OMIM:102530",
      "SCTID:236818008",
      "UMLS:C4225503"
    ],
    "synonyms": [
      "SPATA16 azoospermia",
      "azoospermia caused by mutation in SPATA16",
      "spermatogenic failure 6",
      "spermatogenic failure type 6",
      "SPGF6",
      "acrosome malformation of spermatozoa",
      "globozoospermia",
      "round-headed spermatozoa",
      "spermatozoa, round-headed"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "Any azoospermia in which the cause of the disease is a mutation in the SPATA16 gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6724,
      "label": "spermatogenic failure",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7053
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111910",
          "EFO:0000279",
          "MEDGEN:766708",
          "OMIMPS:258150",
          "UMLS:C3553794"
        ],
        "synonyms": [
          "spermatogenic failure"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A male infertility characterized by dirsuption of the process of sperm development from diploid cells into mature haploid spermatozoa."
      },
      "child_count": 226,
      "reference_id": "MONDO:0004983"
    },
    {
      "id": 16506,
      "label": "male infertility due to globozoospermia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18463
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0112312",
          "GARD:0012502",
          "MEDGEN:1826006",
          "Orphanet:171709",
          "UMLS:C5679591"
        ],
        "synonyms": [
          "Male infertility due to round-headed spermatozoa",
          "male infertility due to globozoospermia",
          "male infertility due to round-headed spermatozoa",
          "round-headed sperm syndrome",
          "globozoospermia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A male infertility due to sperm disorder characterized by the presence, in sperm, of a large majority of round-headed spermatozoa that lack the acrosome and have an aberrant nuclear membrane and midpiece defects. The acrosomeless spermatozoa is not able to penetrate the zona pellucida following intercourse or IVF thus fertilization fails. Fertilization efficiency is also very low following intracytoplasmic spem injection due to the absence of the oocyte activation factor protein PLCzeta."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015746"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6724,
      "label": "spermatogenic failure"
    },
    {
      "id": 16506,
      "label": "male infertility due to globozoospermia"
    }
  ]
}