{
  "id": 8648,
  "label": "Burkitt lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007243",
  "properties": {
    "xrefs": [
      "DOID:8584",
      "EFO:0000309",
      "GARD:0005973",
      "ICD10CM:C83.7",
      "ICD9:200.2",
      "ICDO:9687/3",
      "MEDGEN:2377",
      "MESH:D002051",
      "MedDRA:10006595",
      "MedDRA:10053518",
      "MedDRA:10067184",
      "NCIT:C2912",
      "OMIM:113970",
      "ONCOTREE:BL",
      "Orphanet:543",
      "SCTID:118617000",
      "UMLS:C0006413",
      "icd11.foundation:2100138081"
    ],
    "synonyms": [
      "Burkitt lymphoma",
      "Burkitt lymphoma/leukemia",
      "Burkitt's lymphoma",
      "Burkitt's tumour",
      "Burkitt's tumour or lymphoma",
      "burkitt lymphoma, somatic",
      "small non-cleaved cell lymphoma",
      "small non-cleaved cell lymphoma, Burkitt's type",
      "BL"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare form of malignant mature B-cell non-Hodgkin lymphoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5930
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:706",
          "EFO:0000096",
          "GARD:0024136",
          "ICD9:202.0",
          "MEDGEN:235305",
          "NCIT:C27910",
          "ONCOTREE:MBN",
          "SCTID:269476000",
          "UMLS:C1334633"
        ],
        "synonyms": [
          "mature B-cell lymphocytic neoplasm",
          "mature B-cell neoplasm",
          "mature B-cell neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004949"
    },
    {
      "id": 17660,
      "label": "Epstein-Barr virus-associated lymphoproliferative disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021147",
          "MEDGEN:797800",
          "MedDRA:10068349",
          "Orphanet:289644",
          "UMLS:C2363744"
        ],
        "synonyms": [
          "EBV-associated lymphoproliferative disorder",
          "Epstein-Barr virus-associated malignant lymphoproliferative disorder"
        ],
        "definition": "A range of lymphoproliferative diseases characterized by uncontrolled proliferation of B cells, T cells, or NK cells infected with Epstein-Barr virus. Depending on host immunity and viral factors, viral persistence in host cells can induce lymphoproliferation with a diverse clinical spectrum ranging from simple reactive hyperplasia to aggressive lymphoma/leukemia with unique clinical and pathological presentations."
      },
      "child_count": 11,
      "reference_id": "MONDO:0017343"
    },
    {
      "id": 17875,
      "label": "aggressive B-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021245",
          "MEDGEN:1791561",
          "NCIT:C178541",
          "Orphanet:300846",
          "UMLS:C5555120"
        ],
        "synonyms": [
          "aggressive B-cell NHL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0017595"
    }
  ],
  "children": [
    {
      "id": 7711,
      "label": "colon Burkitt lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        4182,
        8648,
        21140
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024311",
          "MEDGEN:272491",
          "NCIT:C27465",
          "UMLS:C1333083"
        ],
        "synonyms": [
          "Burkitt lymphoma of colon",
          "Burkitts lymphoma of colon",
          "colon Burkitt lymphoma",
          "colon Burkitt's lymphoma",
          "colon Burkitts lymphoma",
          "primary colon Burkitt's lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare Burkitt lymphoma that arises from the colon."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006150"
    },
    {
      "id": 7933,
      "label": "small intestinal Burkitt lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        4030,
        8648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024404",
          "MEDGEN:277650",
          "NCIT:C27409",
          "UMLS:C1335991"
        ],
        "synonyms": [
          "Burkitt lymphoma of small intestine",
          "Burkitts lymphoma of small intestine",
          "primary small intestinal Burkitt's lymphoma",
          "small intestinal Burkitt lymphoma",
          "small intestinal Burkitt's lymphoma",
          "small intestine Burkitt lymphoma",
          "small intestine Burkitt's lymphoma",
          "small intestine Burkitts lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A Burkitt lymphoma that arises from the small intestine."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006416"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells"
    },
    {
      "id": 17660,
      "label": "Epstein-Barr virus-associated lymphoproliferative disorder"
    },
    {
      "id": 17875,
      "label": "aggressive B-cell non-Hodgkin lymphoma"
    }
  ]
}