{
  "id": 8660,
  "label": "hepatocellular carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007256",
  "properties": {
    "xrefs": [
      "DOID:684",
      "DOID:686",
      "EFO:0000182",
      "GARD:0016773",
      "ICD10CM:C22.0",
      "ICDO:8170/3",
      "MEDGEN:389187",
      "MESH:D006528",
      "MedDRA:10049010",
      "NANDO:2200047",
      "NCIT:C3099",
      "NORD:1907",
      "OMIM:114550",
      "ONCOTREE:HCC",
      "Orphanet:88673",
      "UMLS:C2239176",
      "icd11.foundation:1294035808"
    ],
    "synonyms": [
      "HCC",
      "cancer, hepatocellular",
      "carcinoma of liver",
      "carcinoma of liver cells",
      "carcinoma of the liver cells",
      "carcinoma, hepatocellular, malignant",
      "hepatoblastoma, somatic",
      "hepatocellular adenocarcinoma",
      "hepatocellular cancer",
      "hepatocellular cancer, somatic",
      "hepatocellular carcinoma",
      "hepatocellular carcinoma, childhood type, somatic",
      "hepatocellular carcinoma, somatic",
      "hepatoma",
      "liver carcinoma",
      "liver cell cancer (hepatocellular carcinoma)",
      "liver cell carcinoma",
      "primary carcinoma of liver cells",
      "primary carcinoma of the liver cells",
      "adult hepatoma",
      "adult primary hepatocellular carcinoma",
      "hepatoblastoma",
      "hepatoblastoma caused by somatic mutation",
      "liver and intrahepatic bile duct carcinoma",
      "liver cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 18551,
      "label": "carcinoma of liver and intrahepatic biliary tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4735,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021786",
          "MEDGEN:78921",
          "NCIT:C7927",
          "ONCOTREE:HCCIHCH",
          "Orphanet:424936",
          "UMLS:C0279000"
        ],
        "synonyms": [
          "cancer of liver",
          "cancer of liver and intrahepatic biliary tract",
          "cancer of the liver",
          "cancer of the liver and intrahepatic biliary tract",
          "carcinoma of liver",
          "hepatic cancer",
          "liver and intrahepatic bile duct cancer",
          "liver cancer",
          "liver carcinoma",
          "liver/hepatobiliary cancer",
          "carcinoma of liver and IBT",
          "liver and intrahepatic bile duct carcinoma",
          "liver and intrahepatic biliary tract cancer",
          "liver and intrahepatic biliary tract carcinoma",
          "primary liver carcinoma",
          "hepatocellular carcinoma plus intrahepatic cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma."
      },
      "child_count": 14,
      "reference_id": "MONDO:0018531"
    }
  ],
  "children": [
    {
      "id": 5189,
      "label": "hepatocellular clear cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6742,
        8660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5016",
          "GARD:0023418",
          "ICDO:8174/3",
          "MEDGEN:690059",
          "NCIT:C5754",
          "UMLS:C1266020"
        ],
        "synonyms": [
          "clear cell carcinoma of liver cells",
          "clear cell carcinoma of the liver cells",
          "clear cell hepatocellular cancer",
          "clear cell hepatocellular carcinoma",
          "hepatocellular clear cell carcinoma",
          "liver cell clear cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of hepatocellular carcinoma characterized by the presence of clear cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003243"
    },
    {
      "id": 5191,
      "label": "aflatoxin-related hepatocellular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5022",
          "GARD:0023419",
          "MEDGEN:231047",
          "NCIT:C27922",
          "UMLS:C1332222"
        ],
        "synonyms": [
          "aflatoxins-related hepatocellular cancer",
          "aflatoxins-related hepatocellular carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hepatocellular carcinoma that develops following exposure to aflatoxin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003245"
    },
    {
      "id": 5192,
      "label": "sclerosing hepatic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5026",
          "GARD:0023420",
          "ICDO:8172/3",
          "MEDGEN:266088",
          "NCIT:C27388",
          "UMLS:C1266018"
        ],
        "synonyms": [
          "scirrhous hepatocellular cancer",
          "scirrhous hepatocellular carcinoma",
          "sclerosing hepatic carcinoma",
          "sclerosing hepatocellular carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An uncommon type of hepatocelluar carcinoma, morphologically characterized by significant fibrosis around the sinusoid-like spaces and atrophy of the tumor trabeculae."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003246"
    },
    {
      "id": 7763,
      "label": "fibrolamellar hepatocellular carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5015",
          "EFO:1000256",
          "GARD:0021704",
          "ICDO:8171/3",
          "MEDGEN:83122",
          "MESH:C537258",
          "NCIT:C4131",
          "ONCOTREE:FLC",
          "Orphanet:401920",
          "SCTID:253018005",
          "UMLS:C0334287"
        ],
        "synonyms": [
          "FHCC",
          "FLC",
          "fibrolamellar cancer",
          "fibrolamellar carcinoma",
          "fibrolamellar carcinoma of liver cells",
          "fibrolamellar carcinoma of the liver cells",
          "fibrolamellar hepatocarcinoma",
          "fibrolamellar hepatocellular carcinoma",
          "hepatocellular carcinoma, fibrolamellar",
          "hepatocellular fibrolamellar carcinoma",
          "liver cell fibrolamellar carcinoma",
          "oncocytic hepatocellular tumor",
          "oncocytic hepatocellular tumour",
          "polygonal cell type hepatocellular carcinoma with fibrous Stroma",
          "FL-HCC",
          "eosinophilic glassy cell hepatoma",
          "eosinophilic hepatocellular carcinoma with lamellar fibrosis",
          "fibrolamellar oncocytic hepatoma",
          "fibrolamellar variant of hepatocellular carcinoma",
          "hepatocellular carcinoma (fibrolamellar variant)",
          "hepatocellular carcinoma with increased stromal fibrosis",
          "polygonal cell hepatocellular carcinoma with fibrous stroma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A distinctive type of liver cell carcinoma that arises in non-cirrhotic livers and is seen predominantly in young patients. The tumor cells are polygonal and deeply eosinophilic, and are embedded in a fibrous stroma. The prognosis is similar to classical hepatocellular carcinoma that arises in non-cirrhotic livers, and better than hepatocellular carcinoma that arises in cirrhotic livers."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006210"
    },
    {
      "id": 7812,
      "label": "liver diffuse large B-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        6475,
        8660,
        18833
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000323",
          "GARD:0024354",
          "MEDGEN:473542",
          "NCIT:C96843",
          "UMLS:C2184126"
        ],
        "synonyms": [
          "diffuse large B-cell lymphoma of liver",
          "hepatic diffuse large B-cell lymphoma",
          "liver diffuse large B-cell lymphoma",
          "primary hepatic diffuse large B-cell lymphoma",
          "primary liver diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare diffuse large B-cell lymphoma that arises from the liver and the bulk of the tumor is located in the liver."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006268"
    },
    {
      "id": 16799,
      "label": "adult hepatocellular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070328",
          "GARD:0006608",
          "MEDGEN:124633",
          "NCIT:C7956",
          "Orphanet:210159",
          "UMLS:C0279607"
        ],
        "synonyms": [
          "hepatocellular cancer",
          "adult HCC",
          "adult hepatocellular carcinoma",
          "adult hepatoma",
          "adult primary carcinoma of liver cell",
          "adult primary carcinoma of the liver cell",
          "adult primary hepatocellular carcinoma",
          "adult primary hepatoma",
          "adult primary liver cell carcinoma",
          "hepatocellular carcinoma of adults"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Adult hepatocellular carcinoma is the most common primary liver cancer of adulthood. Derived from well-differentiated hepatocytes, it often develops from chronic liver cirrhosis which is most often due to hepatitis B and C virus or alcohol abuse. Symptoms are hepatic mass, abdominal pain and, in advanced stages, jaundice, cachexia and liver failure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016216"
    },
    {
      "id": 18219,
      "label": "pediatric hepatocellular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8005,
        8660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070322",
          "GARD:0009331",
          "MEDGEN:75999",
          "NCIT:C7955",
          "Orphanet:33402",
          "UMLS:C0279606"
        ],
        "synonyms": [
          "hepatocellular cancer",
          "Paediatric carcinoma of the liver cell",
          "Pediatric carcinoma of the liver cell",
          "childhood carcinoma of the liver cell",
          "childhood hepatocellular carcinoma",
          "childhood-onset HCC",
          "childhood-onset hepatocellular carcinoma",
          "paediatric HCC",
          "pediatric HCC",
          "childhood carcinoma of liver cell",
          "childhood hepatoma",
          "childhood liver cell carcinoma",
          "paediatric carcinoma of liver cell",
          "paediatric hepatoma",
          "paediatric liver cell carcinoma",
          "pediatric carcinoma of liver cell",
          "pediatric hepatoma",
          "pediatric liver cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pediatric hepatocellular carcinoma (pediatric HCC) is a rare, aggressive, malignant hepatic tumor that develops mainly in children over 10 years of age."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018055"
    },
    {
      "id": 18657,
      "label": "hepatoblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7212,
        8660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:687",
          "EFO:1000292",
          "GARD:0002657",
          "ICD10CM:C22.2",
          "ICDO:8970/3",
          "MEDGEN:61644",
          "MESH:D018197",
          "MedDRA:10062001",
          "NANDO:2200046",
          "NCIT:C3728",
          "ONCOTREE:LIHB",
          "Orphanet:449",
          "UMLS:C0206624",
          "icd11.foundation:1241693063",
          "icd11.foundation:1556608523"
        ],
        "synonyms": [
          "HBL",
          "hepatoblastoma",
          "hepatoblastoma, malignant",
          "paediatric embryonal hepatoma",
          "paediatric hepatoblastoma",
          "pediatric embryonal hepatoma",
          "pediatric hepatoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Hepatoblastoma (HB) is a malignant hepatic tumor and is the most common pediatric liver cancer. It is characterized by anorexia, weight loss and an enlarged abdomen. HB is more common in patients with familial adenomatous polyposis (FAP), and can occur in patients with other pre-existing liver conditions. About 5% of HB cases are associated with genetic factors, especially overgrowth syndromes, such as Beckwith-Wiedemann syndrome (BWS) or hemihypertrophy."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018666"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 18551,
      "label": "carcinoma of liver and intrahepatic biliary tract"
    }
  ]
}