{
  "id": 8666,
  "label": "cardiac rhythm disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007263",
  "properties": {
    "xrefs": [
      "ICD9:427.9",
      "MEDGEN:2039",
      "NCIT:C2881",
      "SCTID:698247007",
      "UMLS:C0003811"
    ],
    "synonyms": [
      "arrhythmia"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 17,
  "parents": [
    {
      "id": 6967,
      "label": "heart disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:114",
          "EFO:0003777",
          "ICD9:429.89",
          "ICD9:429.9",
          "ICD9:V47.2",
          "MEDGEN:5458",
          "MESH:D006331",
          "NCIT:C3079",
          "SCTID:56265001",
          "UMLS:C0018799",
          "icd11.foundation:1512587470"
        ],
        "synonyms": [
          "cardiac disease",
          "disease of heart",
          "disease or disorder of heart",
          "disorder of heart",
          "disorder of heart/pericardium",
          "heart disease",
          "heart disease or disorder",
          "heart disorder",
          "heart trouble",
          "heart/pericardial disease",
          "heart/pericardial disease or disorder",
          "heart/pericardial disorder",
          "heart/pericardial trouble"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease involving the heart and/or pericardium."
      },
      "child_count": 34,
      "reference_id": "MONDO:0005267"
    }
  ],
  "children": [
    {
      "id": 2763,
      "label": "ventricular fibrillation",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004287",
          "HP:0001663",
          "ICD10CM:I49.01",
          "ICD9:427.41",
          "MEDGEN:21844",
          "MESH:D014693",
          "NANDO:2100052",
          "NANDO:2200227",
          "NCIT:C50799",
          "SCTID:71908006",
          "UMLS:C0042510",
          "icd11.foundation:1662472992"
        ],
        "synonyms": [
          "VF",
          "VFib",
          "fibrillation, ventricular",
          "ventricular fibrillation",
          "ventricular fibrillation (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disorder characterized by an electrocardiographic finding of a rapid grossly irregular ventricular rhythm with marked variability in QRS cycle length, morphology, and amplitude. The rate is typically greater than 300 bpm. (CDISC)"
      },
      "child_count": 1,
      "reference_id": "MONDO:0000190"
    },
    {
      "id": 3118,
      "label": "cardiac arrest",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060319",
          "ICD10CM:I46",
          "ICD10WHO:I46",
          "ICD9:427.5",
          "MEDGEN:5456",
          "MESH:D006323",
          "SCTID:410429000",
          "UMLS:C0018790",
          "icd11.foundation:395422191"
        ],
        "synonyms": [
          "circulatory arrest"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Cessation of breathing and/or cardiac function."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000745"
    },
    {
      "id": 6722,
      "label": "atrial fibrillation",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060224",
          "EFO:0000275",
          "HP:0005110",
          "ICD9:427.31",
          "MEDGEN:445",
          "MESH:D001281",
          "NANDO:2100051",
          "NANDO:2200226",
          "NCIT:C50466",
          "SCTID:49436004",
          "UMLS:C0004238",
          "icd11.foundation:171698302"
        ],
        "synonyms": [
          "AF",
          "AFib",
          "atrial fibrillation",
          "atrial fibrillation (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)"
      },
      "child_count": 3,
      "reference_id": "MONDO:0004981"
    },
    {
      "id": 7134,
      "label": "ventricular tachycardia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005306",
          "ICD10CM:I47.2",
          "MEDGEN:12068",
          "MESH:D017180",
          "NANDO:2100049",
          "NCIT:C50802",
          "SCTID:25569003",
          "UMLS:C0042514",
          "icd11.foundation:1171837620"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC)"
      },
      "child_count": 3,
      "reference_id": "MONDO:0005477"
    },
    {
      "id": 7136,
      "label": "atrial tachycardia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005308",
          "ICD9:427.89",
          "MEDGEN:107485",
          "NANDO:2200218",
          "NCIT:C35481",
          "SCTID:276796006",
          "UMLS:C0546959"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disorder characterized by an electrocardiographic finding of an organized, regular atrial rhythm with atrial rate between 101 and 240 beats per minute. The P wave morphology must be distinct from the sinus P wave morphology. (CDISC)"
      },
      "child_count": 1,
      "reference_id": "MONDO:0005479"
    },
    {
      "id": 14352,
      "label": "torsade-de-pointes syndrome with short coupling interval",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016651",
          "MEDGEN:462201",
          "OMIM:613600",
          "Orphanet:51084",
          "SCTID:718104007",
          "UMLS:C3150851"
        ],
        "synonyms": [
          "torsade DE pointes, short-coupled variant"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Torsade-de-pointes (TdP) syndrome with short coupling interval is a very rare variant of Torsade de pointes, a polymorphic ventricular tachycardia, which is characterized by a short coupling interval of the first TdP beat on electrocardiogram in the absence of any structural heart disease. It manifests in early adulthood with syncope, often results in ventricular fibrillation and shows a high risk of sudden cardiac death."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013317"
    },
    {
      "id": 14970,
      "label": "sinoatrial node dysfunction and deafness",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8666,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017484",
          "MEDGEN:766932",
          "OMIM:614896",
          "Orphanet:324321",
          "UMLS:C3554018"
        ],
        "synonyms": [
          "sinoatrial node dysfunction and deafness",
          "SANDD"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Sinoatrial node dysfunction and deafness is a rare genetic disease characterized by congenital severe to profound deafness with no evidence of vestibular dysfunction, associated with sinoatrial node dysfunction with pronounced bradycardia and increased variability of heart rate at rest and episodic syncopes that may be triggered by enhanced physical activity and stress."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013960"
    },
    {
      "id": 16142,
      "label": "sino-auricular heart block",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:1260"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0015257"
    },
    {
      "id": 18164,
      "label": "multifocal atrial tachycardia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0001235",
          "HP:0011701",
          "ICD9:427.89",
          "MEDGEN:66362",
          "Orphanet:3282",
          "SCTID:49982000",
          "UMLS:C0221158",
          "icd11.foundation:262929566"
        ],
        "synonyms": [
          "MAT",
          "chaotic atrial tachycardia",
          "multifocal atrial tachycardia",
          "multifocal atrial tachycardia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Multifocal atrial tachycardia is a rare supraventricular arrhythmia in neonates and young infants that is characterized by multiple P waves with varying P wave morphology and is usually asymptomatic."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017988"
    },
    {
      "id": 18165,
      "label": "His bundle tachycardia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002706",
          "ICD9:427.89",
          "MEDGEN:21066",
          "MESH:D013613",
          "NCIT:C111646",
          "Orphanet:3283",
          "SCTID:233901002",
          "UMLS:C0039235",
          "icd11.foundation:962827983"
        ],
        "synonyms": [
          "JET",
          "junctional ectopic tachycardia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "His bundle tachycardia is a very rare congenital genetic tachyarrhythmia characterized by incessant tachycardia and high morbidity and mortality."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017989"
    },
    {
      "id": 18676,
      "label": "incessant infant ventricular tachycardia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018832",
          "MEDGEN:573762",
          "Orphanet:45453",
          "SCTID:233908008",
          "UMLS:C0340487",
          "icd11.foundation:1364925734"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Incessant infant ventricular tachycardia is a rare type of ventricular tachycardia (VT) characterized by the presence of tachycardia originating from the ventricles, observed for more than 10% of a 24 hour monitoring period. Patients are either asymptomatic or present congestive heart failure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018685"
    },
    {
      "id": 20148,
      "label": "ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        8666,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1781114",
          "OMIM:115000",
          "UMLS:C5542154"
        ],
        "synonyms": [
          "VACRDS",
          "autosomal dominant cardiac arrhythmia (Kuhn)",
          "ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome",
          "cardiac arrhythmia",
          "extrasystoles"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0020745"
    },
    {
      "id": 23654,
      "label": "sudden arrhythmia death syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:439428",
          "SCTID:735686002",
          "UMLS:C2721586",
          "icd11.foundation:1833795233"
        ],
        "synonyms": [
          "sudden arrhythmic death syndrome",
          "SADS",
          "sudden cardiac death due to cardiac arrhythmia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0054866"
    },
    {
      "id": 23795,
      "label": "cardiac conduction defect",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:78114",
          "NCIT:C78245",
          "OMIM:115080",
          "UMLS:C0264886"
        ],
        "synonyms": [
          "cardiac conduction disorder",
          "conduction disorder",
          "disorder of cardiac conduction",
          "heart conduction disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0100042"
    },
    {
      "id": 24236,
      "label": "sudden cardiac arrest",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:354518",
          "MESH:C1720824",
          "UMLS:C1720824",
          "icd11.foundation:264292672"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "The sudden loss of all heart activity due to an irregular heart rhythm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100511"
    },
    {
      "id": 26353,
      "label": "cardiac conduction disease with or without cardiomyoopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8666,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "OMIMPS:616117",
          "Orphanet:436242"
        ],
        "synonyms": [
          "hereditary atrial tachyarrhythmia-infra-Hisian cardiac conduction disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A rare genetic cardiac disease characterized by variably expressed atrial tachyarrhythmia (such as atrial flutter, paroxysmal or chronic atrial fibrillation, ectopic atrial tachycardia, or multifocal atrial tachycardia), infra-Hisian conduction system disease, and vulnerability to dilated cardiomyopathy. Age of onset ranges between childhood and adulthood."
      },
      "child_count": 4,
      "reference_id": "MONDO:0980715"
    },
    {
      "id": 26601,
      "label": "cardiogenetic rhythm disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8666,
        24272
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "cardiogenetic rhythm disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any cardiac rhythm disorder with a monogenic etiology that includes, but is not limited to, atrial fibrillation, sick sinus syndrome, progressive cardiac conduction disease, ventricular fibrillation, Brugada syndrome, long QT syndrome, short QT syndrome, tachycardia with fibrillation."
      },
      "child_count": 18,
      "reference_id": "MONDO:1010180"
    }
  ],
  "roots": [
    {
      "id": 6967,
      "label": "heart disorder"
    }
  ]
}