{
  "id": 8725,
  "label": "cirrhosis, familial",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007329",
  "properties": {
    "xrefs": [
      "GARD:0024551",
      "MEDGEN:350049",
      "MESH:C566123",
      "NCIT:C84411",
      "OMIM:215600",
      "SCTID:6183001",
      "UMLS:C1861556"
    ],
    "synonyms": [
      "cirrhosis, familial",
      "cryptogenic cirrhosis",
      "hereditary cirrhosis of liver",
      "Indian childhood cirrhosis",
      "Sen syndrome",
      "cirrhosis, Noncryptogenic, susceptibility to",
      "cirrhosis, cryptogenic",
      "cirrhosis, familial, with pulmonary hypertension",
      "copper toxicosis, idiopathic",
      "copper-overload cirrhosis",
      "endemic Tyrolean infantile cirrhosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Cirrhosis in which no causative agent can be identified."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 6879,
      "label": "cirrhosis of liver",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6878
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5082",
          "EFO:0001422",
          "ICD9:571.5",
          "MEDGEN:7368",
          "MESH:D008103",
          "NANDO:2100268",
          "NANDO:2200937",
          "NCIT:C2951",
          "SCTID:19943007",
          "UMLS:C0023890"
        ],
        "synonyms": [
          "cirrhosis",
          "liver cirrhosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005155"
    },
    {
      "id": 23885,
      "label": "telomere syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19146
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026060",
          "MEDGEN:1668986",
          "NCIT:C152065",
          "UMLS:C4727832"
        ],
        "synonyms": [
          "STS",
          "short telomere syndrome"
        ],
        "definition": "Accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased telomere lengths."
      },
      "child_count": 7,
      "reference_id": "MONDO:0100137"
    }
  ],
  "children": [
    {
      "id": 7068,
      "label": "primary biliary cholangitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6624,
        8725
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12236",
          "EFO:1001486",
          "GARD:0007459",
          "ICD10CM:K74.3",
          "ICD9:571.6",
          "MEDGEN:3035",
          "MESH:D008105",
          "MedDRA:10004661",
          "MedDRA:10019137",
          "NANDO:1200439",
          "NCIT:C27167",
          "NORD:1604",
          "OMIMPS:109720",
          "Orphanet:186",
          "SCTID:31712002",
          "UMLS:C0008312",
          "icd11.foundation:649193479"
        ],
        "synonyms": [
          "Hanot syndrome",
          "PBC",
          "chronic non-suppurative destructive cholangitis",
          "chronic nonsuppurative destructive cholangitis",
          "primary Bilary cirrhosis (PBC)",
          "primary biliary cirrhosis",
          "biliary cirrhosis, primary",
          "familial primary biliary cirrhosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005388"
    },
    {
      "id": 18776,
      "label": "isolated congenital hepatic fibrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6624,
        8725
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021995",
          "ICD9:777.8",
          "MEDGEN:40449",
          "MESH:C562378",
          "NANDO:2100267",
          "NANDO:2200936",
          "NCIT:C97071",
          "NORD:1225",
          "Orphanet:485426",
          "SCTID:79607001",
          "UMLS:C0009714"
        ],
        "synonyms": [
          "isolated CHF",
          "Congenital Hepatic Fibrosis",
          "congenital hepatic fibrosis",
          "nonsyndromic congenital hepatic fibrosis",
          "congenital fibrose liver"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A congenital disorder usually inherited in an autosomal recessive pattern. It affects the hepatobiliary system and the kidneys. It is characterized by liver fibrosis, portal hypertension, and renal cysts."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018840"
    },
    {
      "id": 20276,
      "label": "cirrhosis, familial, with antigenemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8725
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025276",
          "MEDGEN:1875236",
          "OMIM:118900",
          "UMLS:C5975708"
        ],
        "synonyms": [
          "cirrhosis, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0021025"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 6879,
      "label": "cirrhosis of liver"
    },
    {
      "id": 23885,
      "label": "telomere syndrome"
    }
  ]
}