{
  "id": 8740,
  "label": "aorta coarctation",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007345",
  "properties": {
    "xrefs": [
      "DOID:0051054",
      "EFO:1001267",
      "GARD:0005828",
      "ICD10CM:Q25.1",
      "ICD9:747.10",
      "MEDGEN:1617",
      "MESH:D001017",
      "MedDRA:10009807",
      "NANDO:2200283",
      "NANDO:2200284",
      "NCIT:C84567",
      "OMIM:120000",
      "Orphanet:1457",
      "SCTID:7305005",
      "UMLS:C0003492",
      "icd11.foundation:1524185114"
    ],
    "synonyms": [
      "aortic coarctation",
      "coarctation of aorta",
      "coarctation of the aorta"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Congenital narrowing of a segment of the aorta. Signs and symptoms include hypertension, muscle weakness, shortness of breath, headaches and leg cramps."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 7210,
      "label": "aortic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2933
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:520",
          "EFO:0005775",
          "ICD9:447.9",
          "MEDGEN:1618",
          "MESH:D001018",
          "NCIT:C101253",
          "SCTID:47040006",
          "UMLS:C0003493"
        ],
        "synonyms": [
          "aorta disease",
          "aorta disease or disorder",
          "disease of aorta",
          "disease or disorder of aorta",
          "disorder of aorta"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Pathology involving the thoracic, thoracoabdominal, or abdominal aorta (including aneurysms). (ACC)"
      },
      "child_count": 17,
      "reference_id": "MONDO:0005561"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:Q00-Q99",
          "MEDGEN:1843482",
          "UMLS:C0694457"
        ],
        "definition": "Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development."
      },
      "child_count": 190,
      "reference_id": "MONDO:0021147"
    }
  ],
  "children": [
    {
      "id": 16288,
      "label": "autosomal dominant coarctation of aorta",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        8740
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018722",
          "MEDGEN:443900",
          "Orphanet:1455",
          "UMLS:C2930803"
        ],
        "synonyms": [
          "aorta coarctation, autosomal dominant",
          "autosomal dominant aorta coarctation"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Autosomal dominant form of aorta coarctation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015445"
    },
    {
      "id": 16289,
      "label": "atypical coarctation of aorta",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8740
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018723",
          "MEDGEN:758831",
          "NANDO:2200284",
          "Orphanet:1456",
          "SCTID:471268000",
          "UMLS:C3496579",
          "icd11.foundation:480830042"
        ],
        "synonyms": [
          "Midaortic syndrome",
          "coarctation of the abdominal aorta",
          "mid-aortic dysplastic syndrome",
          "mid-aortic syndrome",
          "middle aortic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Middle aortic coarctation is a rare vascular anomaly characterized by the segmental narrowing of the abdominal and/or distal descending thoracic aorta with varying involvement of the visceral and renal arteries that commonly presents in children and young adults with early onset and refractory hypertension, abdominal angina, lower-limb claudication and that can lead to life-threatening complications associated with severe hypertension (i.e. myocardial infarction, heart failure, aortic rupture, renal insufficiency and intracranial hemorrhage). It may be due to various congenital or acquired causes, but it is most often secondary to an acquired inflammatory disease (i.e. Takayasu arteritis or giant cell arteritis)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015446"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 7210,
      "label": "aortic disorder"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis"
    }
  ]
}