{
  "id": 8822,
  "label": "cerebral arteriopathy with subcortical infarcts and leukoencephalopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007432",
  "properties": {
    "xrefs": [
      "DOID:13945",
      "GARD:0024558",
      "ICD9:323.9",
      "ICD9:447.8",
      "MEDGEN:199687",
      "NANDO:1200545",
      "OMIMPS:125310",
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    "synonyms": [
      "CADASIL",
      "cerebral arteriopathy with subcortical infaracts and leukoencephalopathy",
      "cerebral arteriopathy with subcortical infarcts and leukoencephalopathy",
      "Casil",
      "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy",
      "dementia, hereditary multi-infarct type"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 7065,
      "label": "vascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:178",
          "EFO:0004264",
          "ICD10CM:I00-I99",
          "ICD10CM:I70-I79",
          "ICD9:442.9",
          "MEDGEN:22621",
          "MESH:D014652",
          "NANDO:2100294",
          "NCIT:C35117",
          "SCTID:27550009",
          "UMLS:C0042373"
        ],
        "synonyms": [
          "disease of vasculature",
          "disease or disorder of vasculature",
          "disorder of vasculature",
          "vascular disorder",
          "vasculature disease",
          "vasculature disease or disorder",
          "vasculopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005385"
    }
  ],
  "children": [
    {
      "id": 3186,
      "label": "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        8822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111035",
          "GARD:0001049",
          "MEDGEN:1634330",
          "MESH:D046589",
          "MedDRA:10065551",
          "NCIT:C84606",
          "NORD:883",
          "OMIM:125310",
          "Orphanet:136",
          "SCTID:390936003",
          "UMLS:C4551768",
          "icd11.foundation:1621899838"
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        "synonyms": [
          "cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy",
          "CADASIL",
          "CADASIL syndrome",
          "CADASIL type 1",
          "CADASIL1",
          "CASIL",
          "autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy type 1",
          "cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1",
          "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1",
          "dementia, hereditary multi-infarct type",
          "hereditary multi-infarct dementia",
          "cerebral arteriopathy with subcortical infarcts and leukoencephalopathy",
          "familial vascular leukoencephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A CADASIL characterized by migraine, strokes, and white matter lesions that has material basis in heterozygous mutation in the NOTCH3 gene on chromosome 19p13."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000914"
    },
    {
      "id": 15757,
      "label": "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111036",
          "GARD:0025015",
          "MEDGEN:895965",
          "OMIM:616779",
          "UMLS:C4225211"
        ],
        "synonyms": [
          "CADASIL caused by mutation in HTRA1",
          "CADASIL type 2",
          "CADASIL2",
          "HTRA1 CADASIL",
          "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any CADASIL in which the cause of the disease is a mutation in the HTRA1 gene."
      },
      "child_count": 1,
      "reference_id": "MONDO:0014768"
    },
    {
      "id": 26324,
      "label": "cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7611,
        8822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061227",
          "GARD:0028122",
          "OMIM:621295"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0979867"
    }
  ],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 7065,
      "label": "vascular disorder"
    }
  ]
}