{
  "id": 8921,
  "label": "multiple endocrine neoplasia type 1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007540",
  "properties": {
    "xrefs": [
      "DOID:10017",
      "GARD:0003829",
      "ICD10CM:E31.21",
      "ICD9:237.4",
      "ICD9:258.01",
      "MEDGEN:9957",
      "MESH:D018761",
      "MedDRA:10028190",
      "NANDO:2200405",
      "NCIT:C3225",
      "NORD:1466",
      "OMIM:131100",
      "Orphanet:652",
      "SCTID:30664006",
      "UMLS:C0025267",
      "icd11.foundation:1638765741"
    ],
    "synonyms": [
      "multiple endocrine adenomatosis",
      "MEA type 1",
      "MEA type I",
      "MEN1",
      "MEN1 multiple endocrine neoplasia",
      "MEN1 syndrome",
      "MEN1-related multiple endocrine neoplasia",
      "Wermer syndrome",
      "Wermer's syndrome",
      "men 1",
      "men type 1",
      "men type I",
      "multiple endocrine adenomatosis type 1",
      "multiple endocrine adenomatosis type I",
      "multiple endocrine adenomatosis, type I",
      "multiple endocrine neoplasia 1",
      "multiple endocrine neoplasia caused by mutation in MEN1",
      "multiple endocrine neoplasia type 1",
      "multiple endocrine neoplasia type 1 syndrome",
      "multiple endocrine neoplasia type I",
      "multiple endocrine neoplasia, type I",
      "MEA 1",
      "MEN1 somatic mutations",
      "endocrine adenomatosis multiple",
      "endocrine adenomatosis, multiple",
      "multiple endocrine neoplasia, type 1"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An autosomal dominant tumor predisposition syndrome caused by pathogenic variants in the MEN1 gene, characterized by an increased risk of tumors of the parathyroid glands, pituitary gland, and foregut neuroendocrine tumors (most commonly pancreatic islet cells)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2903,
      "label": "autosomal dominant disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050736",
          "ICD9:758.5",
          "MEDGEN:539206",
          "SCTID:11164009",
          "UMLS:C0265385"
        ],
        "synonyms": [
          "autosomal dominant disease or disorder",
          "autosomal dominant hereditary disorder",
          "autosomal dominant inherited disorder",
          "disease or disorder, autosomal dominant",
          "disease, autosomal dominant"
        ],
        "definition": "Autosomal dominant form of disease."
      },
      "child_count": 192,
      "reference_id": "MONDO:0000426"
    },
    {
      "id": 16897,
      "label": "familial primary hyperparathyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11973,
        16765,
        20525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002837",
          "MEDGEN:543605",
          "Orphanet:2207",
          "UMLS:C0271846",
          "icd11.foundation:1186866066"
        ],
        "synonyms": [
          "hereditary primary hyperparathyroidism (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An instance of primary hyperparathyroidism (disease) that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 15,
      "reference_id": "MONDO:0016365"
    },
    {
      "id": 17512,
      "label": "multiple endocrine neoplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16050,
        16218,
        20691
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3125",
          "GARD:0021044",
          "ICD10CM:E31.2",
          "ICD9:258.0",
          "ICDO:8360/1",
          "MEDGEN:45036",
          "MESH:D009377",
          "MedDRA:10061299",
          "NANDO:2100148",
          "NCIT:C6432",
          "OMIMPS:131100",
          "Orphanet:276161",
          "SCTID:46724008",
          "UMLS:C0027662"
        ],
        "synonyms": [
          "MEN",
          "men syndrome",
          "men syndromes",
          "multiple endocrine adenomatosis",
          "multiple endocrine neoplasia",
          "multiple endocrine neoplasia syndrome",
          "multiple endocrine neoplasia syndrome(s)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Multiple endocrine neoplasia (MEN) is a group of rare inherited cancer syndromes characterized by the development of two or more endocrine gland tumors, sometimes with tumor development in other tissues or organs."
      },
      "child_count": 9,
      "reference_id": "MONDO:0017169"
    },
    {
      "id": 20437,
      "label": "adrenal gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        7151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003850",
          "GARD:0019765",
          "MEDGEN:1352",
          "NCIT:C2859",
          "ONCOTREE:ADRENAL_GLAND",
          "Orphanet:100091",
          "UMLS:C0001624"
        ],
        "synonyms": [
          "adrenal gland neoplasm (disease)",
          "adrenal gland tumor",
          "adrenal gland tumour",
          "adrenal neoplasm",
          "adrenal neoplasms",
          "adrenal tumor",
          "adrenal tumour",
          "neoplasm of adrenal gland",
          "neoplasm of the adrenal gland",
          "tumor of adrenal gland",
          "tumor of the adrenal gland",
          "tumour of adrenal gland",
          "tumour of the adrenal gland",
          "ADRENAL_GLAND",
          "adrenal/paraganglial tumor",
          "adrenal/paraganglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the adrenal gland."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021227"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2903,
      "label": "autosomal dominant disease"
    },
    {
      "id": 16897,
      "label": "familial primary hyperparathyroidism"
    },
    {
      "id": 17512,
      "label": "multiple endocrine neoplasia"
    },
    {
      "id": 20437,
      "label": "adrenal gland neoplasm"
    }
  ]
}