{
  "id": 8953,
  "label": "esophageal cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007576",
  "properties": {
    "xrefs": [
      "DOID:5041",
      "GARD:0027778",
      "ICD10CM:C15",
      "ICD9:150.3",
      "ICD9:150.4",
      "ICD9:150.5",
      "ICD9:150.8",
      "ICD9:150.9",
      "MEDGEN:107792",
      "NCIT:C7478",
      "OMIM:133239",
      "SCTID:363402007",
      "UMLS:C0546837",
      "icd11.foundation:669033105"
    ],
    "synonyms": [
      "cancer of esophagus",
      "cancer of oesophagus",
      "esophageal cancer",
      "esophageal cancer, somatic",
      "esophageal carcinoma, somatic",
      "esophageal squamous cell carcinoma, somatic",
      "esophagus cancer",
      "malignant esophageal neoplasm",
      "malignant esophageal tumor",
      "malignant esophageal tumour",
      "malignant esophagus neoplasm",
      "malignant esophagus tumor",
      "malignant neoplasm of esophagus",
      "malignant neoplasm of oesophagus",
      "malignant neoplasm of the esophagus",
      "malignant neoplasm of the oesophagus",
      "malignant oesophagus neoplasm",
      "malignant oesophagus tumour",
      "malignant tumor of esophagus",
      "malignant tumor of the esophagus",
      "malignant tumour of oesophagus",
      "malignant tumour of the oesophagus",
      "oesophagus cancer",
      "Ca lower third esophagus",
      "Ca lower third oesophagus",
      "Ca middle third esophagus",
      "Ca middle third oesophagus",
      "malignant neoplasm of distal third of esophagus",
      "malignant neoplasm of distal third of oesophagus",
      "malignant neoplasm of lower third of esophagus",
      "malignant neoplasm of lower third of oesophagus",
      "malignant neoplasm of middle third of esophagus",
      "malignant neoplasm of middle third of oesophagus",
      "malignant neoplasm of proximal third of esophagus",
      "malignant neoplasm of proximal third of oesophagus",
      "malignant neoplasm of upper third esophagus",
      "malignant neoplasm of upper third oesophagus",
      "malignant tumor of abdominal esophagus",
      "malignant tumor of distal third of esophagus",
      "malignant tumor of proximal third of esophagus",
      "malignant tumor of the middle third of the esophagus",
      "malignant tumour of abdominal oesophagus",
      "malignant tumour of distal third of oesophagus",
      "malignant tumour of proximal third of oesophagus",
      "malignant tumour of the middle third of the oesophagus",
      "Aerodigestive tract cancer, susceptibility to",
      "Escc, susceptibility to",
      "esophageal squamous cell carcinoma, susceptibility to",
      "gastric cardia adenocarcinoma, susceptibility to"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A primary or metastatic malignant neoplasm involving the esophagus."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 4587,
      "label": "digestive system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151,
        6733,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3119",
          "ICD10CM:C15-C26",
          "ICD9:239.0",
          "MEDGEN:148231",
          "NCIT:C4890",
          "UMLS:C0751075"
        ],
        "synonyms": [
          "GI tumor",
          "GI tumour",
          "cancer of digestive system",
          "digestive system cancer",
          "gastrointestinal system cancer",
          "malignant digestive system neoplasm",
          "malignant gastrointestinal neoplasm",
          "malignant gastrointestinal system neoplasm",
          "malignant neoplasm of digestive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving any part of the digestive system."
      },
      "child_count": 45,
      "reference_id": "MONDO:0002516"
    },
    {
      "id": 20522,
      "label": "neoplasm of esophagus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5629,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:4547",
          "NCIT:C3028",
          "SCTID:126817006",
          "UMLS:C0014859"
        ],
        "synonyms": [
          "esophageal neoplasm",
          "esophageal neoplasms, benign and malignant",
          "esophageal tumor",
          "esophageal tumors",
          "esophageal tumour",
          "esophageal tumours",
          "esophagus neoplasm",
          "esophagus neoplasm (disease)",
          "esophagus tumor",
          "neoplasm of esophagus",
          "neoplasm of the esophagus",
          "neoplasm of the oesophagus",
          "oesophagus neoplasm",
          "oesophagus neoplasm (disease)",
          "oesophagus tumour",
          "tumor of esophagus",
          "tumor of the esophagus",
          "tumour of oesophagus",
          "tumour of the oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the esophagus."
      },
      "child_count": 10,
      "reference_id": "MONDO:0021355"
    }
  ],
  "children": [
    {
      "id": 3432,
      "label": "esophagus lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6479,
        8953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1106",
          "GARD:0022896",
          "MEDGEN:234231",
          "NCIT:C5687",
          "UMLS:C1333459",
          "icd11.foundation:223819380"
        ],
        "synonyms": [
          "esophageal lymphoma",
          "esophagus lymphoma",
          "lymphoma of esophagus",
          "lymphoma of oesophagus",
          "lymphoma of the esophagus",
          "lymphoma of the oesophagus",
          "primary esophageal lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An extranodal lymphoma that arises from the esophagus with the bulk of the mass located in the esophagus. Dysphagia may be the presenting symptom. The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001188"
    },
    {
      "id": 3435,
      "label": "esophageal melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8953,
        23550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1108",
          "GARD:0027569",
          "MEDGEN:272590",
          "NCIT:C5707",
          "ONCOTREE:ESMM",
          "UMLS:C1333460",
          "icd11.foundation:1371529838"
        ],
        "synonyms": [
          "esophageal melanoma",
          "esophagus melanoma",
          "esophagus melanoma (disease)",
          "melanoma (disease) of esophagus",
          "melanoma (disease) of oesophagus",
          "melanoma of esophagus",
          "melanoma of oesophagus",
          "melanoma of the esophagus",
          "melanoma of the oesophagus",
          "oesophagus melanoma (disease)",
          "mucosal melanoma of the esophagus",
          "mucosal melanoma of the oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A melanoma affecting the esophageal wall. Melanoma in the esophagus is more commonly metastatic than primary. Primary melanomas of the esophagus are polypoid and clinically aggressive. (WHO, 2000)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0001192"
    },
    {
      "id": 3444,
      "label": "esophagus sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8953,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1114",
          "GARD:0022900",
          "MEDGEN:234233",
          "NCIT:C5341",
          "UMLS:C1333466"
        ],
        "synonyms": [
          "esophageal sarcoma",
          "esophagus sarcoma",
          "sarcoma of esophagus",
          "sarcoma of oesophagus",
          "sarcoma of the esophagus",
          "sarcoma of the oesophagus",
          "sarcoma, esophagus",
          "sarcoma, oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant soft tissue neoplasm that arises from the esophagus. Representative examples include Kaposi sarcoma, leiomyosarcoma, rhabdomyosarcoma, and synovial sarcoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001204"
    },
    {
      "id": 18977,
      "label": "carcinoma of esophagus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7738,
        8953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1107",
          "EFO:0002916",
          "GARD:0006383",
          "MEDGEN:56256",
          "MedDRA:10030155",
          "NCIT:C3513",
          "Orphanet:70482",
          "SCTID:372138000",
          "UMLS:C0152018"
        ],
        "synonyms": [
          "Esophageal cancer",
          "carcinoma of esophagus",
          "carcinoma of the esophagus",
          "carcinoma of the oesophagus",
          "esophageal carcinoma",
          "esophagus carcinoma",
          "oesophagus carcinoma",
          "cancer of esophagus",
          "cancer of oesophagus",
          "cancer of the esophagus",
          "cancer of the oesophagus",
          "esophageal cancer",
          "esophageal cancer, NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)."
      },
      "child_count": 10,
      "reference_id": "MONDO:0019086"
    },
    {
      "id": 20503,
      "label": "malignant neoplasm of abdominal esophagus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027888",
          "ICD9:150.2",
          "MEDGEN:141675",
          "NCIT:C4764",
          "SCTID:187724003",
          "UMLS:C0496775"
        ],
        "synonyms": [
          "abdominal part of esophagus cancer",
          "abdominal part of oesophagus cancer",
          "cancer of abdominal part of esophagus",
          "cancer of abdominal part of oesophagus",
          "malignant abdominal part of esophagus neoplasm",
          "malignant abdominal part of oesophagus neoplasm",
          "malignant neoplasm of abdominal part of esophagus",
          "malignant neoplasm of abdominal part of oesophagus",
          "malignant neoplasm of the abdominal esophagus",
          "malignant neoplasm of the abdominal oesophagus",
          "malignant tumor of the abdominal esophagus",
          "malignant tumour of the abdominal oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A cancer that involves the abdominal part of esophagus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021324"
    },
    {
      "id": 20504,
      "label": "malignant neoplasm of thoracic esophagus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027889",
          "ICD9:150.1",
          "MEDGEN:102268",
          "NCIT:C3532",
          "SCTID:187723009",
          "UMLS:C0153411"
        ],
        "synonyms": [
          "cancer of thoracic part of esophagus",
          "cancer of thoracic part of oesophagus",
          "malignant neoplasm of the thoracic esophagus",
          "malignant neoplasm of the thoracic oesophagus",
          "malignant neoplasm of thoracic part of esophagus",
          "malignant neoplasm of thoracic part of oesophagus",
          "malignant thoracic part of esophagus neoplasm",
          "malignant thoracic part of oesophagus neoplasm",
          "thoracic part of esophagus cancer",
          "thoracic part of oesophagus cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A cancer that involves the thoracic part of esophagus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021325"
    },
    {
      "id": 20505,
      "label": "malignant neoplasm of cervical esophagus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027890",
          "ICD9:150.0",
          "MEDGEN:141674",
          "NCIT:C4763",
          "SCTID:187722004",
          "UMLS:C0496773"
        ],
        "synonyms": [
          "cancer of cervical part of esophagus",
          "cancer of cervical part of oesophagus",
          "cervical part of esophagus cancer",
          "cervical part of oesophagus cancer",
          "malignant cervical part of esophagus neoplasm",
          "malignant cervical part of oesophagus neoplasm",
          "malignant neoplasm of cervical part of esophagus",
          "malignant neoplasm of cervical part of oesophagus",
          "malignant neoplasm of the cervical esophagus",
          "malignant neoplasm of the cervical oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A cancer that involves the cervical part of esophagus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021326"
    }
  ],
  "roots": [
    {
      "id": 4587,
      "label": "digestive system cancer"
    },
    {
      "id": 20522,
      "label": "neoplasm of esophagus"
    }
  ]
}