{
  "id": 9007,
  "label": "IgAD1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007644",
  "properties": {
    "xrefs": [
      "GARD:0024568",
      "MEDGEN:419725",
      "MESH:C536290",
      "NCIT:C123434",
      "OMIM:137100",
      "UMLS:C2931161"
    ],
    "synonyms": [
      "IGAD1",
      "IgAD1",
      "immunoglobulin A deficiency, autosomal recessive, autosomal dominant, isolated cases",
      "IMMUNOGLOBULIN A deficiency 1",
      "IgA, selective deficiency of",
      "Immunoglobulin A, selective deficiency of",
      "gamma-A-globulin, selective deficiency of"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Decreased or absent levels of serum immunoglobulin A, with normal serum levels of immunoglobulin G and immunoglobulin M in a patient who is older than 4 years of age and in whom all other causes of hypogammaglobulinemia have been excluded. Affected individuals may be asymptomatic or have frequent infections, allergic reactions, or autoimmune disorders."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3569,
      "label": "selective IgA deficiency disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3570
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060025",
          "DOID:11701",
          "EFO:1001929",
          "GARD:0027574",
          "MEDGEN:883982",
          "MESH:D017098",
          "NANDO:1200347",
          "NANDO:2200720",
          "NCIT:C26964",
          "Orphanet:69127",
          "SCTID:29260007",
          "UMLS:C4049006"
        ],
        "synonyms": [
          "SIgAD",
          "immunoglobulin A deficiency",
          "selective IgA immunodeficiency",
          "IgA deficiencies",
          "deficiencies, IgA",
          "deficiency, IgA",
          "immunoglobulin alpha deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A dysgammaglobulinemia characterized by low or undetectable serum levels of immunoglobulin class A (IgA). It is the most common primary antibody deficiency. It may be inherited or the reversible sequela of infection or certain drugs. It may be caused by decreased or inefficient class-switching from progenitor B cells without any corresponding decreases in the other isotypes. Though affected persons may be asymptomatic, low levels of IgA will reduce the immune system's ability to combat infection where IgA is normally secreted, at mucosal surfaces. Selective IgA deficiency is seen in greater proportion among patients with autoimmune disorders."
      },
      "child_count": 3,
      "reference_id": "MONDO:0001341"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3569,
      "label": "selective IgA deficiency disease"
    }
  ]
}