{
  "id": 9010,
  "label": "hereditary diffuse gastric adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007648",
  "properties": {
    "xrefs": [
      "DOID:0080764",
      "GARD:0010900",
      "MEDGEN:310839",
      "NCIT:C43295",
      "Orphanet:26106",
      "SCTID:716859000",
      "UMLS:C1708349"
    ],
    "synonyms": [
      "FDGC",
      "HDGC",
      "familial diffuse cancer of stomach",
      "familial diffuse gastric cancer",
      "hereditary diffuse cancer of stomach",
      "hereditary diffuse gastric adenocarcinoma",
      "hereditary diffuse gastric cancer",
      "diffuse gastric cancer",
      "signet cell adenocarcinoma",
      "signet ring cell gastric carcinoma",
      "signet ring gastric carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "An autosomal dominant inherited adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of poorly cohesive malignant cells and absence of glandular formations."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6754,
      "label": "diffuse gastric adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6770,
        20704
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6217",
          "EFO:0000402",
          "GARD:0027712",
          "MEDGEN:79019",
          "NCIT:C9159",
          "ONCOTREE:DSTAD",
          "UMLS:C0279635"
        ],
        "synonyms": [
          "adenocarcinoma of linitis plastica type",
          "adenocarcinoma of the linitis plastica type",
          "carcinoma, diffuse type",
          "carcinoma, diffuse type (morphologic abnormality)",
          "diffuse adenocarcinoma of stomach",
          "diffuse adenocarcinoma of the stomach",
          "diffuse gastric adenocarcinoma",
          "diffuse stomach adenocarcinoma",
          "gastric diffuse adenocarcinoma",
          "stomach diffuse type adenocarcinoma",
          "diffuse type stomach adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the stomach. Microscopically, it is characterized by the presence of a diffuse infiltrate, composed of individual adenocarcinoma cells or groups of adenocarcinoma cells in a fibrous or mucoid stroma. Many cells contain mucin droplets, producing a signet-ring configuration."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005017"
    },
    {
      "id": 18536,
      "label": "hereditary gastric cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021758",
          "MEDGEN:1843054",
          "Orphanet:423776",
          "UMLS:C5680075"
        ],
        "synonyms": [
          "hereditary cancer of stomach",
          "hereditary gastric cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Hereditary gastric cancer refers to the occurrence of gastric cancer in a familial context and is described as two or more cases of gastric cancer in first or second degree relatives with at least one case diagnosed before the age of 50. Familial clustering is observed in 10% of all cases of gastric cancer, and includes hereditary diffuse gastric cancer (early onset diffuse-type gastric cancer), gastric adenocarcinoma and proximal polyposis of the stomach and familial intestinal gastric cancer (familial clustering of intestinal type gastric adenocarcinoma). Hereditary gastric cancer can also occur in other hereditary cancer syndromes such as Lynch syndrome, Li-Fraumeni syndrome, familial adenomatous polyposis and juvenile polyposis syndrome."
      },
      "child_count": 8,
      "reference_id": "MONDO:0018502"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6754,
      "label": "diffuse gastric adenocarcinoma"
    },
    {
      "id": 18536,
      "label": "hereditary gastric cancer"
    }
  ]
}