{
  "id": 9011,
  "label": "MALT lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007650",
  "properties": {
    "xrefs": [
      "DOID:0050909",
      "EFO:0000191",
      "GARD:0006485",
      "ICD10CM:C88.4",
      "ICD9:202.80",
      "ICDO:9699/3",
      "MEDGEN:66942",
      "MedDRA:10060707",
      "NCIT:C3898",
      "OMIM:137245",
      "ONCOTREE:EMALT",
      "Orphanet:52417",
      "SCTID:277622004",
      "UMLS:C0242647",
      "Wikipedia:MALT_lymphoma"
    ],
    "synonyms": [
      "Extranodal marginal zone B-cell lymphoma",
      "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue",
      "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma)",
      "Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue",
      "Immunocytoma",
      "MALT lymphoma",
      "MALT-lymphoma",
      "MALToma",
      "lymphoma of mucosa-associated lymphoid tissue",
      "lymphoma, MALT, somatic",
      "mucosa-associated lymphatic tissue lymphoma",
      "mucosa-associated lymphoid tissue lymphoma",
      "extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)",
      "familial primary gastric lymphoma",
      "gastric lymphoma, primary",
      "lymphoma, mucosa-associated lymphoid type"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5930
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:706",
          "EFO:0000096",
          "GARD:0024136",
          "ICD9:202.0",
          "MEDGEN:235305",
          "NCIT:C27910",
          "ONCOTREE:MBN",
          "SCTID:269476000",
          "UMLS:C1334633"
        ],
        "synonyms": [
          "mature B-cell lymphocytic neoplasm",
          "mature B-cell neoplasm",
          "mature B-cell neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004949"
    },
    {
      "id": 17884,
      "label": "marginal zone lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17874,
        22946
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050748",
          "EFO:1000630",
          "GARD:0013237",
          "ICDO:9699/3",
          "MEDGEN:277950",
          "NCIT:C4341",
          "ONCOTREE:MZL",
          "Orphanet:300912",
          "SCTID:447100004",
          "UMLS:C1367654"
        ],
        "synonyms": [
          "MZBCL",
          "MZL",
          "lymphoma of marginal zone B cell",
          "marginal zone B cell lymphoma",
          "marginal zone B-cell lymphoma",
          "marginal zone lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A usually indolent mature B-cell lymphoma, arising from the marginal zone of lymphoid tissues. It is characterized by the presence of small to medium sized atypical lymphocytes. It comprises three entities, according to the anatomic sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph nodes without evidence of extranodal disease; and splenic marginal zone B-cell lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood."
      },
      "child_count": 8,
      "reference_id": "MONDO:0017604"
    }
  ],
  "children": [
    {
      "id": 7687,
      "label": "breast mucosa-associated lymphoid tissue lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4198,
        9011
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024300",
          "MEDGEN:234051",
          "NCIT:C35688",
          "UMLS:C1332633"
        ],
        "synonyms": [
          "breast MALT lymphoma",
          "breast mucosa-associated lymphoid tissue lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue that arises from the breast as a primary tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006119"
    },
    {
      "id": 7779,
      "label": "gastric mucosa-associated lymphoid tissue lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7558,
        9011,
        18536,
        23066
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000274",
          "GARD:0024340",
          "MEDGEN:232547",
          "NCIT:C5266",
          "UMLS:C1333782"
        ],
        "synonyms": [
          "MALT lymphoma of stomach",
          "MALT lymphoma of the stomach",
          "MALToma of stomach",
          "MALToma of the stomach",
          "gastric MALT lymphoma",
          "gastric MALToma",
          "gastric mucosa-associated lymphoid tissue lymphoma",
          "primary MALT lymphoma of stomach",
          "primary MALT lymphoma of the stomach",
          "primary gastric B-cell MALT lymphoma",
          "primary gastric MALT lymphoma",
          "stomach MALT lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A low grade, indolent B-cell lymphoma, usually associated with Helicobacter pylori infection. Morphologically it is characterized by a dense mucosal atypical lymphocytic (centrocyte-like cell) infiltrate with often prominent lymphoepithelial lesions and plasmacytic differentiation. Approximately 40% of gastric MALT lymphomas carry the t(11;18)(q21;q21). Such cases are resistant to Helicobacter pylori therapy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006226"
    },
    {
      "id": 7937,
      "label": "small intestinal mucosa-associated lymphoid tissue lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4030,
        7558,
        9011
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024407",
          "MEDGEN:233452",
          "NCIT:C5635",
          "UMLS:C1336004"
        ],
        "synonyms": [
          "MALT lymphoma of small bowel",
          "MALT lymphoma of small intestine",
          "MALT lymphoma of the small bowel",
          "MALT lymphoma of the small intestine",
          "MALToma of small bowel",
          "MALToma of small intestine",
          "MALToma of the small bowel",
          "MALToma of the small intestine",
          "mucosa-associated lymphoid tissue lymphoma of small bowel",
          "mucosa-associated lymphoid tissue lymphoma of small intestine",
          "mucosa-associated lymphoid tissue lymphoma of the small bowel",
          "mucosa-associated lymphoid tissue lymphoma of the small intestine",
          "small bowel MALT lymphoma",
          "small bowel MALToma",
          "small bowel mucosa-associated lymphoid tissue lymphoma",
          "small intestinal mucosa-associated lymphoid tissue lymphoma",
          "small intestine MALT lymphoma",
          "small intestine MALToma",
          "small intestine mucosa-associated lymphoid tissue lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A mucosa-associated lymphoid tissue lymphoma (MALT) that arises from the small intestine. The morphologic characteristics are similar to those seen in gastric MALT lymphomas, with the exception of the lymphoepithelial lesions that are less prominent in the small intestine."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006420"
    },
    {
      "id": 7965,
      "label": "thyroid gland mucosa-associated lymphoid tissue lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9011
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000591",
          "GARD:0024421",
          "MEDGEN:234948",
          "NCIT:C7601",
          "UMLS:C1336754"
        ],
        "synonyms": [
          "thyroid MALT lymphoma",
          "thyroid mucosa-associated lymphoid tissue lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An extranodal marginal zone B-cell lymphoma arising from mucosa-associated lymphoid tissue in the thyroid gland. The vast majority of cases are associated with chronic lymphocytic thyroiditis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006464"
    },
    {
      "id": 23468,
      "label": "tonsillar lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6479,
        7558,
        8421,
        9011,
        18718
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025917",
          "MEDGEN:234432",
          "NCIT:C5918",
          "UMLS:C1336765"
        ],
        "synonyms": [
          "Primary tonsillar lymphoma",
          "lymphoma of the tonsil",
          "lymphoma of tonsil",
          "tonsil lymphoma",
          "tonsillar lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A primary lymphoma that affects the tonsil and the bulk of the tumor is in this anatomic area. The majority of cases are B-cell non-Hodgkin lymphomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044884"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells"
    },
    {
      "id": 17884,
      "label": "marginal zone lymphoma"
    }
  ]
}