{
  "id": 9146,
  "label": "multiple system atrophy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007803",
  "properties": {
    "xrefs": [
      "DOID:4752",
      "EFO:1001050",
      "GARD:0007079",
      "MEDGEN:98276",
      "MESH:D019578",
      "MedDRA:10064060",
      "NANDO:1200034",
      "NCIT:C84909",
      "NORD:1472",
      "Orphanet:102",
      "UMLS:C0393571",
      "icd11.foundation:1890931931"
    ],
    "synonyms": [
      "MSA",
      "Shy-Drager syndrome",
      "multisystem atrophy",
      "Shy-dragger syndrome (formerly)",
      "autonomic failure, Pure",
      "hypotension, orthostatic",
      "susceptibility to multiple system atrophy 1"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure (cardiovascular and/or urinary), parkinsonism, cerebellar impairment and corticospinal signs with a median survival of 6-9 years."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 2963,
      "label": "synucleinopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7208,
        20409
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050890",
          "GARD:0022781",
          "MEDGEN:1682194",
          "MESH:D000080874",
          "UMLS:C5191670"
        ],
        "synonyms": [
          "alpha synucleinopathies",
          "synucleinopathies"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibers or glial cells. [url:http://en.wikipedia.org/wiki/Synucleinopathies ]"
      },
      "child_count": 4,
      "reference_id": "MONDO:0000510"
    },
    {
      "id": 7073,
      "label": "movement disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:480",
          "EFO:0004280",
          "ICD9:333.90",
          "ICD9:333.99",
          "MEDGEN:10113",
          "MESH:D009069",
          "NCIT:C116757",
          "SCTID:60342002",
          "UMLS:C0026650"
        ],
        "synonyms": [
          "movement disease",
          "movement disorder",
          "movement disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Neurological conditions resulting in abnormal voluntary or involuntary movement, which may impact the speed, fluency, quality and ease of movement."
      },
      "child_count": 54,
      "reference_id": "MONDO:0005395"
    }
  ],
  "children": [
    {
      "id": 5100,
      "label": "striatonigral degeneration",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9146,
        18954,
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4751",
          "GARD:0023374",
          "ICD10CM:G23.2",
          "ICD9:333.0",
          "MEDGEN:124366",
          "MESH:D020955",
          "NCIT:C125695",
          "OMIMPS:271930",
          "SCTID:29618004",
          "UMLS:C0270733",
          "icd11.foundation:195535779"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive neurodegenerative disorder caused by a disruption in the connection between the striatum and the substantia nigra. It is a type of multiple system atrophy (MSA). Signs and symptoms include rigidity, instability, impaired speech, and slow movements."
      },
      "child_count": 9,
      "reference_id": "MONDO:0003122"
    },
    {
      "id": 16934,
      "label": "multiple system atrophy, cerebellar type",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9146
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020565",
          "MEDGEN:1843304",
          "NANDO:1200035",
          "Orphanet:227510",
          "UMLS:C5554234",
          "icd11.foundation:1585600114"
        ],
        "synonyms": [
          "MSA, cerebellar type",
          "MSA-c",
          "sporadic OPCA type 1",
          "sporadic olivopontocerebellar atrophy type 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Multiple system atrophy, cerebellar type (MSA-c) is a form of multiple system atrophy (MSA) with predominant cerebellar features (gait and limb ataxia, oculomotor dysfunction, and dysarthria)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016418"
    },
    {
      "id": 18610,
      "label": "pure autonomic failure",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3525,
        9146
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010428",
          "MEDGEN:98293",
          "MESH:D054970",
          "NORD:1948",
          "Orphanet:441",
          "SCTID:84438001",
          "UMLS:C0393911",
          "icd11.foundation:734022291"
        ],
        "synonyms": [
          "Bradbury Eggleston syndrome",
          "Bradbury-Eggleston syndrome",
          "PAF",
          "Pure dysautonomia",
          "Pure idiopatic dysautonomia",
          "idiopathic orthostatic hypotension",
          "idiopathic orthostatic hypotension (a symptom)",
          "orthostatic hypotension (a symptom)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018608"
    },
    {
      "id": 19814,
      "label": "multiple system atrophy, parkinsonian type",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9146,
        20335
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019604",
          "MEDGEN:1842393",
          "NANDO:1200036",
          "Orphanet:98933",
          "UMLS:C5554235",
          "icd11.foundation:296753000"
        ],
        "synonyms": [
          "MSA, parkinsonian type",
          "MSA-p"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Multiple system atrophy, parkinsonian type (MSA-p) is a form of multiple system atrophy (MSA) with predominant parkinsonian features (bradykinesia, rigidity, irregular jerky postural tremor, and postural instability)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020352"
    }
  ],
  "roots": [
    {
      "id": 2963,
      "label": "synucleinopathy"
    },
    {
      "id": 7073,
      "label": "movement disorder"
    }
  ]
}