{
  "id": 9157,
  "label": "IgE responsiveness, atopic",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007817",
  "properties": {
    "xrefs": [
      "MEDGEN:327063",
      "MESH:C564133",
      "NCIT:C3116",
      "OMIM:147050",
      "UMLS:C1840253"
    ],
    "synonyms": [
      "IgE responsiveness, atopic",
      "IgE, elevated level of",
      "immediate hypersensitivity",
      "type 1 hypersensitivity",
      "type 1 hypersensitivity reaction",
      "type I hypersensitivity",
      "type I hypersensitivity reaction",
      "type I immediate hypersensitivity reaction",
      "Atopic hypersensitivity",
      "IGER",
      "IgE response underlying allergic asthma and rhinitis",
      "IgE responsiveness, ATOPIC",
      "IgE, level of",
      "Immunoglobulin E, basic level of, in serum",
      "atopy, susceptibility to"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060056",
          "EFO:1002003",
          "MEDGEN:759636",
          "NCIT:C3114",
          "SCTID:473010000",
          "UMLS:C3532523"
        ],
        "synonyms": [
          "allergic reaction",
          "sensitive",
          "sensitivity",
          "hypersensitive",
          "hypersensitivity",
          "hypersensitivity reaction"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000605"
    },
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease"
    },
    {
      "id": 5714,
      "label": "hereditary disease"
    }
  ]
}