{
  "id": 9159,
  "label": "solitary median maxillary central incisor syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007819",
  "properties": {
    "xrefs": [
      "GARD:0004877",
      "MEDGEN:326686",
      "MESH:C537342",
      "OMIM:147250",
      "Orphanet:2286",
      "SCTID:707609006",
      "UMLS:C1840235",
      "icd11.foundation:1834868112"
    ],
    "synonyms": [
      "SMMCI",
      "single median maxillary central incisor",
      "single upper central incisor",
      "solitary median maxillary central incisor syndrome",
      "Fused incisors",
      "SMMCI syndrome",
      "incisors fused",
      "incisors, Fused",
      "single central maxillary incisor",
      "solitary MEDIAN maxillary central incisor"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A hereditary autosomal dominant condition characterized primarily by single (unpaired) deciduous and permanent maxillary central incisors and short stature. Growth hormone deficiencies may also be present. Mutations in the SHH gene have been identified."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 9085,
      "label": "holoprosencephaly 3",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16852
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110875",
          "GARD:0024572",
          "MEDGEN:327125",
          "MESH:C564181",
          "OMIM:142945",
          "UMLS:C1840529"
        ],
        "synonyms": [
          "HLP3",
          "HPE3",
          "SHH holoprosencephaly",
          "Shh holoprosencephaly",
          "holoprosencephaly 3",
          "holoprosencephaly caused by mutation in SHH",
          "holoprosencephaly caused by mutation in Shh",
          "holoprosencephaly type 3",
          "Hlp3"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any holoprosencephaly in which the cause of the disease is a mutation in the SHH gene."
      },
      "child_count": 1,
      "reference_id": "MONDO:0007733"
    },
    {
      "id": 17558,
      "label": "microform holoprosencephaly",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16852
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111380",
          "GARD:0017290",
          "MEDGEN:1711978",
          "Orphanet:280200",
          "UMLS:C5393309",
          "icd11.foundation:44293173"
        ],
        "synonyms": [
          "HPE, minor form",
          "HPE-L",
          "HoloprosencC)phalie, minor form",
          "Holoprosencéphalie, minor form",
          "Microform HPE",
          "holoprosencephaly-like"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Microform holoprosencephaly is a benign form of holoprosencephaly (HPE) characterized by midline defects without the typical HPE defect in brain cleavage."
      },
      "child_count": 3,
      "reference_id": "MONDO:0017219"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 9085,
      "label": "holoprosencephaly 3"
    },
    {
      "id": 17558,
      "label": "microform holoprosencephaly"
    }
  ]
}