{
  "id": 9197,
  "label": "isolated cloverleaf skull syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007861",
  "properties": {
    "xrefs": [
      "GARD:0003115",
      "MEDGEN:98141",
      "MESH:C536884",
      "OMIM:148800",
      "Orphanet:2343",
      "SCTID:254022009",
      "UMLS:C0432126"
    ],
    "synonyms": [
      "isolated cloverleaf skull syndrome",
      "KLEEBLATTSCHAEDEL",
      "Kleeblattschadel",
      "Kleeblattschaedel deformity syndrome",
      "Kleeblattschaedel syndrome",
      "Kleeblattschaedel-deformity syndrome",
      "cloverleaf skull",
      "cloverleaf skull syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "Isolated cloverleaf skull syndrome is a form of craniosynostosis involving multiple sutures (coronal, lambdoidal, sagittal and metopic) characterized by a trilobular skull of varying severity (frontal towering and bossing, temporal bulging and a flat posterior skull), dysmorphic features (downslanting palpebral fissures, midface hypoplasia, and extreme proptosis) and that is complicated by hydrocephalus, cerebral venous hypertension, developmental delay/intellectual disability and hind brain herniation."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16200,
      "label": "isolated craniosynostosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1863457",
          "NANDO:2200843",
          "Orphanet:139390",
          "UMLS:C5848302"
        ],
        "synonyms": [
          "nonsyndromic craniosynostosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A craniosynostosis that is not part of a larger syndrome."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015337"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16200,
      "label": "isolated craniosynostosis"
    }
  ]
}