{
  "id": 9287,
  "label": "familial medullary thyroid carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007958",
  "properties": {
    "xrefs": [
      "DOID:0050547",
      "GARD:0016901",
      "MEDGEN:322311",
      "MESH:C536911",
      "NCIT:C46099",
      "OMIM:155240",
      "Orphanet:99361",
      "UMLS:C1833921"
    ],
    "synonyms": [
      "medullary thyroid carcinoma",
      "familial MTC",
      "familial medullary thyroid carcinoma",
      "hereditary medullary thyroid gland carcinoma",
      "hereditary thyroid medullary carcinoma",
      "thyroid carcinoma, familial medullary",
      "Fmtc",
      "MTC",
      "Mtc1"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An instance of thyroid medullary carcinoma that is caused by an inherited modification of the individual's genome."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16159,
      "label": "medullary thyroid gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        6768
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3973",
          "GARD:0007004",
          "HP:0002865",
          "MEDGEN:66772",
          "MedDRA:10027101",
          "NANDO:2201054",
          "NCIT:C3879",
          "ONCOTREE:THME",
          "Orphanet:1332",
          "SCTID:255032005",
          "UMLS:C0238462",
          "icd11.foundation:578519098"
        ],
        "synonyms": [
          "C cell carcinoma",
          "MTC",
          "carcinoma of parafollicular cell",
          "carcinoma, C-cell, malignant",
          "medullary carcinoma",
          "medullary carcinoma of the thyroid",
          "medullary carcinoma of the thyroid gland",
          "medullary carcinoma of thyroid",
          "medullary carcinoma of thyroid gland",
          "medullary thyroid cancer",
          "medullary thyroid carcinoma",
          "medullary thyroid gland carcinoma",
          "parafollicular cell carcinoma",
          "thyroid gland medullary cancer",
          "thyroid gland medullary carcinoma",
          "thyroid gland neuroendocrine carcinoma",
          "thyroid medullary carcinoma",
          "THME",
          "medullary thyroid cancer (MTC)",
          "thyroid cancer, medullary",
          "thyroid carcinoma, medullary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015277"
    },
    {
      "id": 18918,
      "label": "multiple endocrine neoplasia type 2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16049,
        17512
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0003830",
          "ICD9:194.8",
          "ICD9:258.02",
          "MEDGEN:887211",
          "MedDRA:10028191",
          "NANDO:2200406",
          "NCIT:C123329",
          "NORD:1467",
          "Orphanet:653",
          "SCTID:61808009",
          "UMLS:C4048306",
          "icd11.foundation:1837913809"
        ],
        "synonyms": [
          "MEN2",
          "multiple endocrine neoplasia type 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Multiple endocrine neoplasia type 2 (MEN2) is a multiple endocrine neoplasia, a polyglandular cancer syndrome characterized by the occurrence of medullary thyroid carcinoma (MTC), pheochromocytoma (PCC), in one variant, primary hyperparathyroidism (PHPT). There are three forms: MEN2A, MEN2B, and familial medullary thyroid carcinoma (FMTC)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0019003"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16159,
      "label": "medullary thyroid gland carcinoma"
    },
    {
      "id": 18918,
      "label": "multiple endocrine neoplasia type 2"
    }
  ]
}