{
  "id": 9363,
  "label": "tropical spastic paraparesis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008039",
  "properties": {
    "xrefs": [
      "DOID:321",
      "EFO:0007527",
      "GARD:0008208",
      "ICD10CM:G04.1",
      "ICD9:323.01",
      "MEDGEN:18298",
      "MESH:D015493",
      "MedDRA:10044696",
      "NANDO:1200206",
      "OMIM:159580",
      "Orphanet:289326",
      "SCTID:714279000",
      "UMLS:C0030481",
      "icd11.foundation:1043229589"
    ],
    "synonyms": [
      "HAM/TSP",
      "HTLV-1-associated myelopathy/tropical spastic paraparesis",
      "Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis",
      "Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis",
      "TSP",
      "ham/TSP",
      "tropical spastic paraplegia",
      "HTLV-1 associated myelopathy/tropical spastic paraparesis",
      "Human T-cell leukaemia virus type 1 associated myelopathy/tropical spastic paraparesis",
      "Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis",
      "familial spastic paraparesis, HTLV-1-associated",
      "ham",
      "myelopathy, HTLV-1-associated",
      "tropical spastic paraparesis (formerly)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7417,
      "label": "human T-lymphotropic virus 1 infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6834
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0007316",
          "GARD:0009645",
          "MEDGEN:6919",
          "MESH:D015490",
          "UMLS:C0020097"
        ],
        "synonyms": [
          "Human T-lymphotropic virus 1 caused disease or disorder",
          "Human T-lymphotropic virus 1 disease or disorder",
          "Human T-lymphotropic virus 1 infectious disease",
          "human T-lymphotropic virus 1 infectious disease",
          "HTLV-1",
          "Human T lymphotropic virus type 1"
        ],
        "definition": "A viral infectious disease that results in increased proliferation of affected CD4 lymphocytes, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. The person infected with HTLV-1 eventually develop an often rapidly fatal leukemia, while others will develop a debilitative myelopathy, uveitis, infectious dermatitis, or another inflammatory disorder."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005801"
    },
    {
      "id": 19708,
      "label": "infectious disorder of the nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799,
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:349.89",
          "MEDGEN:108926",
          "NCIT:C27590",
          "Orphanet:98010",
          "SCTID:128116006",
          "UMLS:C0597039"
        ],
        "synonyms": [
          "nervous system infectious disease",
          "nervous system infectious disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A infectious disease that involves the nervous system."
      },
      "child_count": 20,
      "reference_id": "MONDO:0020010"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7417,
      "label": "human T-lymphotropic virus 1 infectious disease"
    },
    {
      "id": 19708,
      "label": "infectious disorder of the nervous system"
    }
  ]
}