{
  "id": 9364,
  "label": "transient myeloproliferative syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008040",
  "properties": {
    "xrefs": [
      "DOID:0060888",
      "GARD:0012765",
      "HP:0005534",
      "ICDO:9898/1",
      "MEDGEN:331782",
      "MESH:C563551",
      "NCIT:C82339",
      "OMIM:159595",
      "ONCOTREE:TAM",
      "Orphanet:420611",
      "SCTID:721307000",
      "UMLS:C1834582"
    ],
    "synonyms": [
      "MST",
      "TAM",
      "TMD",
      "Transient abnormal myelopoiesis associated with Down syndrome",
      "leukemia, transient, of Down syndrome",
      "transient abnormal myelopoiesis",
      "transient leukaemia",
      "transient leurkemia of Down syndrome",
      "transient myeloproliferative disease",
      "transient myeloproliferative disorder",
      "transient myeloproliferative syndrome",
      "transient myeloproliferative syndrome (disease)",
      "Mst",
      "leukemia, transient",
      "myeloproliferative syndrome, transient"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients the myeloid proliferation undergoes spontaneous remission."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 19727,
      "label": "myeloproliferative neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6892,
        16513,
        20376
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2226",
          "EFO:0002428",
          "GARD:0009319",
          "ICD9:238.79",
          "ICDO:9960/3",
          "ICDO:9975/1",
          "MEDGEN:220955",
          "MedDRA:10028576",
          "NCIT:C4345",
          "ONCOTREE:MPN",
          "Orphanet:98274",
          "SCTID:425333006",
          "UMLS:C1292778"
        ],
        "synonyms": [
          "CMPD",
          "MPD",
          "MPN",
          "chronic myeloproliferative disease",
          "chronic myeloproliferative disorder",
          "chronic myeloproliferative neoplasm",
          "myeloproliferative disorder",
          "myeloproliferative neoplasm",
          "myeloproliferative neoplasm, chronic",
          "myeloproliferative tumor",
          "myeloproliferative tumour",
          "CMPD, U",
          "chronic myeloproliferative disorders",
          "myeloproliferative neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)"
      },
      "child_count": 39,
      "reference_id": "MONDO:0020076"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 19727,
      "label": "myeloproliferative neoplasm"
    }
  ]
}