{
  "id": 9409,
  "label": "cyclic hematopoiesis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008090",
  "properties": {
    "xrefs": [
      "DOID:5339",
      "GARD:0006229",
      "ICD10CM:D70.4",
      "ICD9:288.02",
      "MEDGEN:65121",
      "MESH:C536227",
      "MedDRA:10053176",
      "NANDO:1200354",
      "NANDO:2200746",
      "NCIT:C3820",
      "OMIM:162800",
      "Orphanet:2686",
      "SCTID:191347008",
      "UMLS:C0221023"
    ],
    "synonyms": [
      "CH",
      "CN",
      "cyclic agranulocytosis",
      "cyclic hematopoiesis",
      "dysplasia, myelocytic periodic",
      "neutropenia, cyclic",
      "periodic neutropenia",
      "cyclic neutropenia",
      "neutropenia cyclic"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A hematologic disorder caused by a mutation in the ELANE (ELA2) gene; clinical manifestations include recurrent neutropenia with resultant susceptibility to infection leading to fever."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16076,
      "label": "constitutional neutropenia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3689,
        10564
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019809",
          "MEDGEN:1785816",
          "NCIT:C61242",
          "Orphanet:101987",
          "UMLS:C3805116",
          "icd11.foundation:87096615"
        ],
        "synonyms": [
          "congenital neutropenia",
          "genetic infantile agranulocytosis",
          "infantile genetic agranulocytosis",
          "Kostmann disease",
          "Kostmann neutropenia",
          "Kostmann syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare disorder characterized by recurrent infantile infections and absence of neutrophils in the peripheral blood."
      },
      "child_count": 26,
      "reference_id": "MONDO:0015134"
    },
    {
      "id": 29331,
      "label": "ELANE-related neutropenia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3689,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028170"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Any neutropenia in which the cause of the disease is a mutation in the ELANE gene."
      },
      "child_count": 4,
      "reference_id": "MONDO:1060165"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16076,
      "label": "constitutional neutropenia"
    },
    {
      "id": 29331,
      "label": "ELANE-related neutropenia"
    }
  ]
}