{
  "id": 9420,
  "label": "sick sinus syndrome 2, autosomal dominant",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008102",
  "properties": {
    "xrefs": [
      "GARD:0018284",
      "MEDGEN:320273",
      "MESH:C563513",
      "OMIM:163800",
      "UMLS:C1834144"
    ],
    "synonyms": [
      "HCN4 sick sinus syndrome",
      "sick sinus syndrome 2, autosomal dominant",
      "sick sinus syndrome caused by mutation in HCN4",
      "SSS2",
      "Sss, autosomal dominant",
      "atrial fibrillation with Bradyarrhythmia",
      "sick sinus syndrome 2",
      "sick sinus syndrome 2 with or without Cardiac noncompaction and/Or ascending aorta dilation",
      "sinus bradycardia syndrome, familial, autosomal dominant",
      "sinus node disease, familial, autosomal dominant"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Any sick sinus syndrome in which the cause of the disease is a mutation in the HCN4 gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 13129,
      "label": "familial sick sinus syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4004,
        26601
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013663",
          "MEDGEN:573766",
          "MESH:C563907",
          "MedDRA:10040639",
          "OMIMPS:608567",
          "Orphanet:166282",
          "SCTID:233913007",
          "UMLS:C0340491",
          "icd11.foundation:1495462959"
        ],
        "synonyms": [
          "familial sinus node dysfunction",
          "hereditary sick sinus syndrome",
          "SSS1",
          "sick sinus syndrome 1, autosomal recessive"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Sick sinus syndrome is a rare cardiac rhythm disease, usually of the elderly, characterized by electrocardiographic findings of sinus bradycardia, atrial fibrillation, atrial tachycardia sinus arrest, or sino-atrial block, and that manifest with symptoms like syncope, dizziness, palpitations, fatigue, or even heart failure. It results from malfunction of the cardiac conduction system, probably secondary to degenerative fibrosis of nodal tissue in the elderly or secondary to cardiac disorders in younger patients."
      },
      "child_count": 8,
      "reference_id": "MONDO:0012061"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 13129,
      "label": "familial sick sinus syndrome"
    }
  ]
}