{
  "id": 9481,
  "label": "ovarian cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008170",
  "properties": {
    "xrefs": [
      "DOID:2394",
      "ICD10CM:C56",
      "ICD9:183.0",
      "MEDGEN:216027",
      "MESH:D010051",
      "NCIT:C7431",
      "OMIM:167000",
      "Orphanet:213500",
      "SCTID:363443007",
      "UMLS:C1140680",
      "icd11.foundation:685124533"
    ],
    "synonyms": [
      "ovarian neoplasm",
      "ovary neoplasm",
      "tumor of the ovary",
      "tumour of the ovary",
      "cancer of ovary",
      "cancer of the ovary",
      "malignant neoplasm of ovary",
      "malignant neoplasm of the ovary",
      "malignant ovarian neoplasm",
      "malignant ovarian tumor",
      "malignant ovarian tumour",
      "malignant ovary neoplasm",
      "malignant tumor of ovary",
      "malignant tumor of the ovary",
      "malignant tumour of ovary",
      "malignant tumour of the ovary",
      "ovarian cancer",
      "ovarian cancer, somatic",
      "ovarian malignant tumor",
      "ovarian malignant tumour",
      "ovary cancer",
      "ovarian cancer, epithelial",
      "primary ovarian cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 3637,
      "label": "female reproductive organ cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        20384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:120",
          "EFO:1001331",
          "ICD10CM:C51-C58",
          "ICD9:184",
          "MEDGEN:195944",
          "NCIT:C4913",
          "SCTID:126907002",
          "UMLS:C0699889"
        ],
        "synonyms": [
          "cancer of female reproductive organ",
          "female reproductive cancer",
          "female reproductive organ cancer",
          "gynecologic cancer",
          "malignant female reproductive organ neoplasm",
          "malignant female reproductive system neoplasm",
          "malignant female reproductive system tumor",
          "malignant female reproductive system tumour",
          "malignant gynecologic neoplasm",
          "malignant gynecologic tumor",
          "malignant gynecologic tumour",
          "malignant neoplasm of female reproductive organ",
          "malignant neoplasm of female reproductive system",
          "malignant neoplasm of the female reproductive system",
          "malignant tumor of female reproductive system",
          "malignant tumor of the female reproductive system",
          "malignant tumour of female reproductive system",
          "malignant tumour of the female reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the female reproductive system. Representative examples include endometrial carcinoma, cervical carcinoma, ovarian carcinoma, uterine corpus leiomyosarcoma, adenosarcoma, malignant mixed mesodermal (mullerian) tumor, and gestational choriocarcinoma."
      },
      "child_count": 18,
      "reference_id": "MONDO:0001416"
    },
    {
      "id": 20309,
      "label": "ovarian neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7207,
        20384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003893",
          "ICD9:239.5",
          "MEDGEN:181539",
          "NCIT:C4984",
          "SCTID:123843001",
          "UMLS:C0919267"
        ],
        "synonyms": [
          "neoplasm of ovary",
          "neoplasm of the ovary",
          "ovarian neoplasm",
          "ovarian tumor",
          "ovarian tumors",
          "ovarian tumour",
          "ovarian tumours",
          "ovary neoplasm",
          "ovary neoplasm (disease)",
          "ovary tumor",
          "ovary tumour",
          "tumor of ovary",
          "tumor of the ovary",
          "tumour of ovary",
          "tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant neoplasm involving the ovary."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021068"
    }
  ],
  "children": [
    {
      "id": 4342,
      "label": "ovarian malignant mesothelioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7834,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2143",
          "GARD:0023089",
          "MEDGEN:274089",
          "NCIT:C40444",
          "UMLS:C1518721"
        ],
        "synonyms": [
          "malignant mesothelioma (disease) of ovary",
          "ovarian malignant mesothelioma",
          "ovary malignant mesothelioma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare malignant mesothelial neoplasm that usually involves both the ovarian surface and the ovarian stroma. In most cases there is bilateral ovarian involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002223"
    },
    {
      "id": 4343,
      "label": "malignant ovarian cyst",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5223,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2145",
          "GARD:0023090",
          "MEDGEN:116000",
          "NCIT:C3843",
          "UMLS:C0235770"
        ],
        "synonyms": [
          "malignant ovarian cyst",
          "malignant ovarian cyst (disease)",
          "ovarian cyst (disease), malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A cystic cancerous tumor arising from the ovary."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002224"
    },
    {
      "id": 4344,
      "label": "ovarian sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9481,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2146",
          "GARD:0023091",
          "MEDGEN:128881",
          "NCIT:C8267",
          "SCTID:423627007",
          "UMLS:C0280746"
        ],
        "synonyms": [
          "ovarian sarcoma",
          "ovary sarcoma",
          "sarcoma of ovary",
          "sarcoma of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, aggressive malignant mesenchymal neoplasm that arises from the ovary. The prognosis is poor."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002225"
    },
    {
      "id": 4346,
      "label": "ovarian lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6792,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2150",
          "GARD:0023093",
          "MEDGEN:276669",
          "NCIT:C40021",
          "UMLS:C1518720"
        ],
        "synonyms": [
          "lymphoma of ovary",
          "ovarian lymphoma",
          "ovary lymphoma",
          "primary ovarian lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A lymphoma that affects the ovary. Lymphomatous involvement of the ovary is rare and in approximately half of the cases both ovaries are affected."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002227"
    },
    {
      "id": 4348,
      "label": "ovarian Wilms tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7641,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2153",
          "GARD:0023094",
          "MEDGEN:275296",
          "NCIT:C40443",
          "UMLS:C1518746"
        ],
        "synonyms": [
          "ovarian Wilms tumor",
          "ovarian Wilms' tumor",
          "ovarian Wilms' tumour",
          "ovary Wilms tumor",
          "ovary Wilms tumour",
          "ovarian Wilms' cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An embryonal neoplasm arising from the ovary with morphologic features resembling Wilms tumor of the kidney. It occurs during the reproductive age and may present as a rapidly growing adnexal mass."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002230"
    },
    {
      "id": 4561,
      "label": "ovarian neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9481,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3002",
          "GARD:0023145",
          "MEDGEN:277459",
          "NCIT:C5237",
          "UMLS:C1335172"
        ],
        "synonyms": [
          "neuroendocrine neoplasm of ovary",
          "neuroendocrine neoplasm of the ovary",
          "neuroendocrine tumour of ovary",
          "ovarian neuroendocrine neoplasm",
          "ovary NET",
          "ovary neuroendocrine neoplasm",
          "ovary neuroendocrine tumor",
          "ovary neuroendocrine tumor, well differentiated, low or intermediate grade",
          "ovary neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial neoplasm with neuroendocrine differentiation that arises from the ovary. It includes carcinoid tumor, small cell carcinoma pulmonary type, and large cell neuroendocrine carcinoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002481"
    },
    {
      "id": 4893,
      "label": "ovarian adenosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7274,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4115",
          "GARD:0023286",
          "MEDGEN:277458",
          "NCIT:C7317",
          "UMLS:C1335169"
        ],
        "synonyms": [
          "adenosarcoma of ovary",
          "ovarian Mullerian adenosarcoma",
          "ovarian Müllerian adenosarcoma",
          "ovarian adenosarcoma",
          "ovarian mesodermal adenosarcoma",
          "ovarian mullerian adenosarcoma",
          "ovary adenosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A biphasic neoplasm that arises from the ovary and is characterized by the presence of mullerian-type epithelial tissue in a mesenchymal sarcomatous stroma. The presence of a high grade sarcomatous component is associated with recurrences and metastases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002880"
    },
    {
      "id": 5742,
      "label": "ovarian endometrioid adenocarcinofibroma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4991,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6445",
          "GARD:0023711",
          "ICDO:8381/3",
          "MEDGEN:276664",
          "NCIT:C40060",
          "UMLS:C1518711"
        ],
        "synonyms": [
          "ovarian endometrioid adenocarcinofibroma",
          "ovarian endometrioid malignant adenofibroma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm of the ovary characterized by the presence of malignant glandular cells resembling endometrial cells in a fibrotic stroma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003879"
    },
    {
      "id": 16819,
      "label": "familial ovarian cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020467",
          "MEDGEN:1803368",
          "Orphanet:213517",
          "UMLS:C5679802",
          "icd11.foundation:1484739866"
        ],
        "synonyms": [
          "familial ovarian cancer",
          "familial ovarian malignant tumor",
          "familial ovarian malignant tumour",
          "hereditary ovarian cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An instance of ovarian cancer that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 4,
      "reference_id": "MONDO:0016248"
    },
    {
      "id": 18447,
      "label": "malignant epithelial tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347,
        6734,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2151",
          "GARD:0009362",
          "MEDGEN:577291",
          "MESH:C538090",
          "NCIT:C40026",
          "Orphanet:398934",
          "SCTID:254849005",
          "UMLS:C0346161"
        ],
        "synonyms": [
          "epithelial cancer of ovary",
          "malignant ovarian epithelial tumor",
          "malignant ovarian epithelial tumour",
          "malignant ovarian surface epithelial-stromal neoplasm",
          "malignant ovarian surface epithelial-stromal tumor",
          "malignant ovarian surface epithelial-stromal tumour",
          "ovarian epithelial cancer",
          "ovarian epithelial tumor, malignant",
          "ovarian malignant epithelial tumor",
          "ovarian malignant epithelial tumour",
          "ovarian stromal cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An invasive malignant tumor that originates from the surface epithelium of the ovary. It is composed of malignant epithelial cells and stroma. Representative examples include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, clear cell adenocarcinoma, and malignant Brenner tumor."
      },
      "child_count": 18,
      "reference_id": "MONDO:0018364"
    },
    {
      "id": 18448,
      "label": "malignant non-epithelial tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021650",
          "MEDGEN:1843209",
          "Orphanet:398940",
          "UMLS:C5680039"
        ],
        "synonyms": [
          "non-epithelial cancer of ovary",
          "ovarian malignant non-epithelial tumor",
          "ovarian malignant non-epithelial tumour",
          "ovarian non-epithelial cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0018365"
    }
  ],
  "roots": [
    {
      "id": 3637,
      "label": "female reproductive organ cancer"
    },
    {
      "id": 20309,
      "label": "ovarian neoplasm"
    }
  ]
}