{
  "id": 9508,
  "label": "late-onset Parkinson disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008199",
  "properties": {
    "xrefs": [
      "DOID:0060892",
      "GARD:0017684",
      "MEDGEN:463618",
      "OMIM:168600",
      "Orphanet:411602",
      "SCTID:716662004",
      "UMLS:C3160718"
    ],
    "synonyms": [
      "LOPD",
      "PARK",
      "PD",
      "Parkinson disease, age of onset, modifier, Multifactorial",
      "Parkinson disease, late-onset",
      "Parkinson disease, late-onset, susceptibility to, Multifactorial",
      "Parkinson disease, susceptibility to, Multifactorial",
      "autosomal dominant late-onset Parkinson disease",
      "hereditary late onset Parkinson disease",
      "hereditary late-onset Parkinson disease",
      "late-onset Parkinson disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A Parkinson disease that begins after around the age of 50."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6901,
      "label": "Parkinson disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20335,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14330",
          "ICD10CM:G20",
          "ICD10WHO:G20",
          "ICD9:332",
          "ICD9:332.0",
          "MEDGEN:10590",
          "MESH:D010300",
          "NANDO:1200010",
          "NCIT:C26845",
          "OMIMPS:168600",
          "Orphanet:319705",
          "SCTID:49049000",
          "UMLS:C0030567",
          "birnlex:2098",
          "icd11.foundation:296066191"
        ],
        "synonyms": [
          "PD",
          "Parkinson disease",
          "Parkinson's disease",
          "paralysis agitans"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005180"
    }
  ],
  "children": [
    {
      "id": 9509,
      "label": "autosomal dominant Parkinson disease 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9508
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060367",
          "GARD:0018474",
          "MEDGEN:357008",
          "MESH:C566823",
          "OMIM:168601",
          "UMLS:C1868595"
        ],
        "synonyms": [
          "autosomal dominant Parkinson disease 1",
          "autosomal dominant Parkinson disease type 1",
          "PARK1",
          "Parkinson disease 1, autosomal dominant",
          "Parkinson disease 1, autosomal dominant Lewy body",
          "atypical Parkinson disease",
          "autosomal dominant Parkinson's disease 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008200"
    },
    {
      "id": 12658,
      "label": "autosomal dominant Parkinson disease 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9508
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060895",
          "GARD:0018475",
          "MEDGEN:381361",
          "MESH:C565324",
          "OMIM:605543",
          "UMLS:C1854182"
        ],
        "synonyms": [
          "autosomal dominant Parkinson disease 4",
          "autosomal dominant Parkinson disease type 4",
          "PARK4",
          "Parkinson disease 4, autosomal dominant",
          "Parkinson disease 4, autosomal dominant Lewy body",
          "autosomal dominant Parkinson's disease 4"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A late onset Parkinson disease that has material basis in heterozygous triplication of the alpha-synuclein gene (SNCA) on chromosome 4q22."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011562"
    },
    {
      "id": 12849,
      "label": "autosomal dominant Parkinson disease 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9508
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060371",
          "GARD:0018476",
          "MEDGEN:339628",
          "OMIM:607060",
          "UMLS:C1846862"
        ],
        "synonyms": [
          "LRRK2 Parkinson disease",
          "Parkinson disease 8",
          "Parkinson disease caused by mutation in LRRK2",
          "autosomal dominant Parkinson disease 8",
          "autosomal dominant Parkinson disease type 8",
          "PARK8",
          "Parkinson disease 8, autosomal dominant",
          "autosomal dominant Parkinson's disease 8"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any Parkinson disease in which the cause of the disease is a mutation in the LRRK2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011764"
    },
    {
      "id": 14098,
      "label": "autosomal recessive Parkinson disease 14",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9508,
        18173
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060900",
          "GARD:0012568",
          "MEDGEN:414488",
          "MESH:C567844",
          "OMIM:612953",
          "Orphanet:199351",
          "SCTID:720466001",
          "UMLS:C2751842"
        ],
        "synonyms": [
          "PARK14",
          "PLA2G6 hereditary late onset Parkinson disease",
          "PLA2G6-related dystonia-parkinsonism",
          "autosomal recessive Parkinson disease type 14",
          "dystonia-parkinsonism, Paisan-Ruiz type",
          "hereditary late onset Parkinson disease caused by mutation in PLA2G6",
          "Parkinson disease 14, autosomal recessive",
          "adult-onset dystonia - parkinsonism",
          "autosomal recessive Parkinson's disease 14",
          "dystonia-Parkinsonism, adult-onset"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare neurodegenerative disease usually presenting before the age of 30 and which is characterized by dystonia, L-dopa-responsive parkinsonism, pyramidal signs and rapid cognitive decline."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013060"
    },
    {
      "id": 14650,
      "label": "Parkinson disease 17",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9508
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060897",
          "GARD:0018478",
          "MEDGEN:481763",
          "OMIM:614203",
          "UMLS:C3280133"
        ],
        "synonyms": [
          "Parkinson disease 17",
          "Parkinson disease caused by mutation in VPS35",
          "Parkinson disease type 17",
          "VPS35 Parkinson disease",
          "PARK17",
          "Parkinson's disease 17"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any Parkinson disease in which the cause of the disease is a mutation in the VPS35 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013625"
    },
    {
      "id": 15602,
      "label": "Parkinson disease 21",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9508
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111251",
          "GARD:0018480",
          "MEDGEN:903105",
          "OMIM:616361",
          "UMLS:C4225353"
        ],
        "synonyms": [
          "PARK21",
          "Parkinson disease 21",
          "Parkinson disease type 21"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0014604"
    },
    {
      "id": 15734,
      "label": "Parkinson disease 22, autosomal dominant",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9508
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080504",
          "GARD:0025012",
          "MEDGEN:907886",
          "OMIM:616710",
          "UMLS:C4225238"
        ],
        "synonyms": [
          "CHCHD2 Parkinson disease",
          "PARK22",
          "Parkinson disease 22, autosomal dominant",
          "Parkinson disease 22, autosomal dominant; PARK22",
          "Parkinson disease caused by mutation in CHCHD2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any Parkinson disease in which the cause of the disease is a mutation in the CHCHD2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014742"
    }
  ],
  "roots": [
    {
      "id": 6901,
      "label": "Parkinson disease"
    }
  ]
}