{
  "id": 9533,
  "label": "periodontitis, aggressive 1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008226",
  "properties": {
    "xrefs": [
      "DOID:0061237",
      "DOID:1474",
      "EFO:0006342",
      "GARD:0024610",
      "ICD9:523.5",
      "MESH:D010520",
      "OMIM:170650"
    ],
    "synonyms": [
      "periodontitis 1, juvenile",
      "periodontitis, aggressive, type 1",
      "periodontitis, aggressive, 1",
      "periodontitis, juvenile",
      "periodontitis, prepubertal"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "A localized aggressive periodontitis, formerly called localized juvenile periodontitis. It is a destructive form of periodontitis characterized by ALVEOLAR BONE LOSS of the MOLARS and INCISORS. Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 25051,
      "label": "CTSC-related disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19138
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026566"
        ],
        "synonyms": [
          "CTSC-related disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Any ectodermal dysplasia syndrome in which the cause of the disease is a variation in the CTSC gene. Variations in the CTSC gene can result in (1) Papillon-Lefevre syndrome (PLS) characterized by palmoplantar keratoderma, severe periodontitis affecting deciduous and permanent dentitions, and premature loss of dentition, (2) Haim-Munk syndrome (HMS) with additional features of arachnodactly, acroosteolysis, pesplanus, and onychogryphosis, (3) aggressive periodontitis 1 (AP1) characterized by severe and protracted gingival infections, leading to tooth loss. All three phenotypes are associated with autosomal recessive inheritance."
      },
      "child_count": 3,
      "reference_id": "MONDO:0800465"
    },
    {
      "id": 26375,
      "label": "periodontitis, aggressive",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "OMIMPS:170650"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0980757"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 25051,
      "label": "CTSC-related disorder"
    },
    {
      "id": 26375,
      "label": "periodontitis, aggressive"
    }
  ]
}