{
  "id": 9550,
  "label": "Pick disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008243",
  "properties": {
    "xrefs": [
      "DOID:11870",
      "EFO:0003096",
      "GARD:0024611",
      "ICD10CM:G31.01",
      "ICD9:331.11",
      "MEDGEN:116020",
      "MESH:D020774",
      "NCIT:C85008",
      "OMIM:172700",
      "SCTID:13092008",
      "UMLS:C0236642"
    ],
    "synonyms": [
      "PICK disease of brain",
      "Pick disease",
      "lobar atrophy of brain",
      "Pick disease of the brain",
      "Pick's disease",
      "dementia with lobar atrophy and neuronal cytoplasmic inclusions",
      "lobar atrophy of the brain"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A rare neurodegenerative disorder leading to dementia. It is characterized by frontotemporal lobar degeneration with accumulation of tau proteins which form Pick bodies."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17600,
      "label": "frontotemporal dementia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16360,
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9255",
          "GARD:0008436",
          "ICD10CM:G31.0",
          "MEDGEN:83266",
          "MESH:D057180",
          "MedDRA:10068968",
          "NANDO:1200548",
          "NCIT:C84719",
          "Orphanet:282",
          "UMLS:C0338451",
          "icd11.foundation:831337417"
        ],
        "synonyms": [
          "FTD",
          "MSTD",
          "frontotemporal lobe dementia (FLDEM)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders, characterized by progressive changes in behavior, executive dysfunction and language impairment, as a result of degeneration of the medial prefrontal and frontoinsular cortices. Four clinical subtypes have been identified: semantic dementia, progressive non-fluent aphasia, behavioral variant FTD and right temporal lobar atrophy."
      },
      "child_count": 8,
      "reference_id": "MONDO:0017276"
    },
    {
      "id": 21293,
      "label": "cerebral degeneration",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7208,
        7209
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:331.9",
          "MEDGEN:56343",
          "SCTID:418143002",
          "UMLS:C0154671"
        ],
        "synonyms": [
          "cerebral degeneration",
          "neurodegenerative disease of telencephalon",
          "telencephalon neurodegenerative disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neurodegenerative disease that involves the telencephalon."
      },
      "child_count": 4,
      "reference_id": "MONDO:0024238"
    },
    {
      "id": 23499,
      "label": "cerebral cortex disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7209
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:688117",
          "SCTID:128128003",
          "UMLS:C1263847"
        ],
        "synonyms": [
          "cerebral cortex disease",
          "cerebral cortex disease or disorder",
          "disease of cerebral cortex",
          "disease or disorder of cerebral cortex",
          "disorder of cerebral cortex"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease or disorder that involves the cerebral cortex."
      },
      "child_count": 6,
      "reference_id": "MONDO:0044996"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17600,
      "label": "frontotemporal dementia"
    },
    {
      "id": 21293,
      "label": "cerebral degeneration"
    },
    {
      "id": 23499,
      "label": "cerebral cortex disorder"
    }
  ]
}