{
  "id": 9682,
  "label": "rheumatoid arthritis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008383",
  "properties": {
    "xrefs": [
      "DOID:7148",
      "EFO:0000685",
      "HP:0001370",
      "ICD9:714.0",
      "MEDGEN:2078",
      "MESH:D001172",
      "NCIT:C2884",
      "OMIM:180300",
      "Orphanet:284130",
      "SCTID:69896004",
      "UMLS:C0003873",
      "icd11.foundation:576319925"
    ],
    "synonyms": [
      "RA",
      "rheumatoid arthritis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 3005,
      "label": "autoimmune disorder of musculoskeletal system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4222,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060032"
        ],
        "synonyms": [
          "musculoskeletal system autoimmune disease",
          "musculoskeletal system hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the musculoskeletal system."
      },
      "child_count": 6,
      "reference_id": "MONDO:0000589"
    },
    {
      "id": 7203,
      "label": "rheumatic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1575",
          "EFO:0005755",
          "ICD9:729.0",
          "MEDGEN:3157",
          "MESH:D012216",
          "NANDO:2100151",
          "NANDO:2100152",
          "NCIT:C27204",
          "SCTID:396332003",
          "UMLS:C0009326",
          "Wikipedia:Rheumatism"
        ],
        "synonyms": [
          "rheumatic disease",
          "rheumatologic disorder",
          "collagen disease",
          "collagen vascular disease",
          "connective tissue disease",
          "disease, rheumatic",
          "diseases, rheumatic",
          "enthesopathies",
          "enthesopathy",
          "inflammatory rheumatism",
          "musculoskeletal pain disorder",
          "rheumatism"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Inflammatory and degenerative diseases of connective tissue structures, such as arthritis."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005554"
    },
    {
      "id": 7223,
      "label": "arthritic joint disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4665,
        8264,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:848",
          "EFO:0005856",
          "MEDGEN:2043",
          "MESH:D001168",
          "NCIT:C2883",
          "SCTID:3723001",
          "UMLS:C0003864",
          "Wikipedia:Arthritis"
        ],
        "synonyms": [
          "arthritis",
          "inflammation of skeletal joint",
          "skeletal joint inflammation",
          "inflammatory disorder of joint"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain."
      },
      "child_count": 39,
      "reference_id": "MONDO:0005578"
    }
  ],
  "children": [
    {
      "id": 6382,
      "label": "rheumatoid arthritis-associated interstitial lung disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6971,
        9682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:849",
          "ICD9:714.81",
          "MEDGEN:681135",
          "SCTID:398726004",
          "UMLS:C0994344"
        ],
        "synonyms": [
          "RA-ILD",
          "rheumatoid lung disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A group of lung problems related to rheumatoid arthritis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004586"
    },
    {
      "id": 6906,
      "label": "chronic childhood arthritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "NCIT:C27179",
          "SCTID:410793008",
          "Wikipedia:Juvenile_idiopathic_arthritis"
        ],
        "synonyms": [
          "JRA",
          "Juvenile rheumatoid arthritis",
          "Juvenile rheumatoid arthritis (AQ)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An older, deprecated term that encompassed three major types of autoimmune or autoinflammatory arthritis in children: systemic-onset, pauciarticular, or polyarticular arthritis. The juvenile rheumatoid arthritis classification system has been replaced by the International League of Associations for Rheumatology (ILAR) juvenile idiopathic arthritis classification system."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005185"
    },
    {
      "id": 6999,
      "label": "ankylosing spondylitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5796,
        6822,
        9682,
        22983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7147",
          "EFO:0003898",
          "ICD10CM:M45",
          "ICD10WHO:M45",
          "ICD9:720.0",
          "MEDGEN:11561",
          "MESH:D013167",
          "NANDO:1200870",
          "NCIT:C84564",
          "Orphanet:825",
          "SCTID:9631008",
          "UMLS:C0038013"
        ],
        "synonyms": [
          "ankylosing spondylarthritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine."
      },
      "child_count": 8,
      "reference_id": "MONDO:0005306"
    },
    {
      "id": 8972,
      "label": "Felty syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        9682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11042",
          "EFO:0007269",
          "GARD:0008234",
          "ICD10CM:M05.0",
          "ICD9:714.1",
          "MEDGEN:4674",
          "MESH:D005258",
          "MedDRA:10016386",
          "NCIT:C84712",
          "NORD:1135",
          "OMIM:134750",
          "Orphanet:47612",
          "SCTID:57160007",
          "UMLS:C0015773"
        ],
        "synonyms": [
          "Felty syndrome",
          "Felty's syndrome",
          "rheumatoid arthritis with splenoadenomegaly and leukopenia",
          "splenomegaly-neutropenia-rheumatoid arthritis syndrome",
          "familial Felty's syndrome",
          "rheumatoid arthritis, splenomegaly and neutropenia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007603"
    },
    {
      "id": 12930,
      "label": "psoriatic arthritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        9682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9008",
          "EFO:0003778",
          "ICD10CM:L40.5",
          "ICD9:696.0",
          "MEDGEN:2077",
          "MESH:D015535",
          "NANDO:2201059",
          "NCIT:C61277",
          "Orphanet:40050",
          "SCTID:156370009",
          "UMLS:C0003872",
          "icd11.foundation:868183264"
        ],
        "synonyms": [
          "arthritis psoriatica",
          "arthropathic psoriasis",
          "psoriatic arthritis, susceptibility to",
          "psoriatic arthritis, susceptibility to, 1",
          "susceptibility to psoriatic arthritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Joint inflammation associated with psoriasis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0011849"
    },
    {
      "id": 21196,
      "label": "polyarticular juvenile rheumatoid arthritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010967",
          "MEDGEN:551885",
          "SCTID:445479007",
          "UMLS:C0311221"
        ],
        "synonyms": [
          "Juvenile polyarthritis rheumatoid factor negative",
          "Juvenile polyarthritis rheumatoid factor positive",
          "Polyarticular juvenile rheumatoid arthritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0023249"
    },
    {
      "id": 23179,
      "label": "rheumatoid vasculitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9682,
        22010
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007577",
          "MEDGEN:69122",
          "MESH:D056653",
          "NANDO:1200265",
          "SCTID:400054000",
          "UMLS:C0240903",
          "icd11.foundation:1398254566"
        ],
        "synonyms": [
          "rheumatoid vasculitis",
          "Vasculitides, rheumatoid",
          "rheumatoid Vasculitides",
          "vasculitis, rheumatoid"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Necrotizing VASCULITIS of small and medium size vessels, developing as a complication in RHEUMATOID ARTHRITIS patients. It is characterized by peripheral vascular lesions, cutaneous ulcers, peripheral gangrene, and mononeuritis multiplex."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043267"
    }
  ],
  "roots": [
    {
      "id": 3005,
      "label": "autoimmune disorder of musculoskeletal system"
    },
    {
      "id": 7203,
      "label": "rheumatic disorder"
    },
    {
      "id": 7223,
      "label": "arthritic joint disease"
    }
  ]
}