{
  "id": 9726,
  "label": "small cell lung carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008433",
  "properties": {
    "xrefs": [
      "DOID:5409",
      "DOID:5411",
      "EFO:0000702",
      "GARD:0009344",
      "ICD9:162.9",
      "MEDGEN:57450",
      "MESH:D055752",
      "NCIT:C4917",
      "OMIM:182280",
      "ONCOTREE:SCLC",
      "Orphanet:70573",
      "SCTID:254632001",
      "UMLS:C0149925",
      "icd11.foundation:1800431439"
    ],
    "synonyms": [
      "SCLC",
      "oat cell carcinoma",
      "oat cell carcinoma (morphologic abnormality)",
      "poorly differentiated endocrine neoplasm",
      "Small cell lung cancer",
      "lung oat cell carcinoma",
      "lung small cell carcinoma",
      "lung small cell neuroendocrine carcinoma",
      "oat cell carcinoma of lung",
      "oat cell carcinoma of the lung",
      "oat cell lung carcinoma",
      "small cell cancer of the lung, somatic",
      "small cell carcinoma of lung",
      "small cell carcinoma of the lung",
      "small cell lung cancer",
      "small cell neuroendocrine carcinoma of lung",
      "small cell neuroendocrine carcinoma of the lung",
      "small-cell cancer of lung",
      "SCLC1",
      "small cell cancer of the lung"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Small cell lung cancer (SCLC) is a highly aggressive malignant neoplasm, accounting for 10-15% of lung cancer cases, characterized byrapid growth, and early metastasis. SCLC usually manifests as a large hilar mass with bulky mediastinal lymphadenopathy presenting clinically with chest pain, persistent cough, dyspnea, wheezing, hoarseness, hemoptysis, loss of appetite, weight loss, and neurological and endocrine paraneoplastic syndromes. SCLC is primarily reported in elderly people with a history of long-term tobacco exposure."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 2894,
      "label": "small cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050685",
          "EFO:0008524",
          "GARD:0022765",
          "ICDO:8041/3",
          "ICDO:8042/3",
          "MEDGEN:90748",
          "MESH:D018288",
          "NCIT:C3915",
          "NCIT:C4099",
          "SCTID:11010461000119101",
          "UMLS:C0334239"
        ],
        "synonyms": [
          "oat cell cancer",
          "oat cell carcinoma",
          "small cell NEC",
          "small cell cancer",
          "small cell car. (extrapulmonary)",
          "small cell carcinoma",
          "small cell carcinoma (extrapulmonary)",
          "small cell neuroendocrine carcinoma",
          "intermediate cell small cell carcinoma",
          "small cell carcinoma - intermediate cell",
          "small cell carcinoma, intermediate cell",
          "small cell carcinoma, intermediate cell (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble \"oat cells\" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early."
      },
      "child_count": 18,
      "reference_id": "MONDO:0000402"
    },
    {
      "id": 6862,
      "label": "lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        10167
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3905",
          "EFO:0001071",
          "MEDGEN:195765",
          "NCIT:C4878",
          "UMLS:C0684249",
          "icd11.foundation:947165291"
        ],
        "synonyms": [
          "cancer of lung",
          "cancer of the lung",
          "lung cancer",
          "lung cancer, NOS",
          "carcinoma of lung",
          "carcinoma of the lung",
          "lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the lung"
      },
      "child_count": 20,
      "reference_id": "MONDO:0005138"
    },
    {
      "id": 7117,
      "label": "lung neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19314,
        20356
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5410",
          "EFO:0005220",
          "GARD:0024190",
          "ICD9:209.61",
          "MEDGEN:277303",
          "NCIT:C5670",
          "ONCOTREE:LNET",
          "SCTID:707594002",
          "UMLS:C1334452"
        ],
        "synonyms": [
          "lung NET",
          "lung neuroendocrine neoplasm",
          "lung neuroendocrine tumor",
          "lung neuroendocrine tumor, well differentiated, low or intermediate grade",
          "lung neuroendocrine tumour",
          "neuroendocrine neoplasm of lung",
          "neuroendocrine neoplasm of the lung",
          "pulmonary neuroendocrine neoplasm",
          "pulmonary neuroendocrine tumor",
          "pulmonary neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A low, intermediate, or high grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor, atypical carcinoid tumor, small cell carcinoma, large cell neuroendocrine carcinoma, and combined carcinoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005454"
    }
  ],
  "children": [
    {
      "id": 5364,
      "label": "occult small cell lung carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9726
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5414",
          "GARD:0023509",
          "MEDGEN:233791",
          "NCIT:C6683",
          "UMLS:C1335099"
        ],
        "synonyms": [
          "occult small cell carcinoma of lung",
          "occult small cell carcinoma of the lung",
          "occult small cell lung carcinoma",
          "lung occult small cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A small cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003437"
    },
    {
      "id": 5365,
      "label": "combined small cell lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7728,
        9726
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5421",
          "GARD:0023510",
          "ICDO:8045/3",
          "MEDGEN:234167",
          "NCIT:C9137",
          "ONCOTREE:CSCLC",
          "UMLS:C1333125",
          "icd11.foundation:392248394"
        ],
        "synonyms": [
          "combined small and large cell lung cancer",
          "combined small and large cell lung carcinoma",
          "combined small cell and large cell lung carcinoma",
          "combined small cell carcinoma of lung",
          "combined small cell carcinoma of the lung",
          "combined small cell lung cancer",
          "combined small cell lung carcinoma",
          "combined type small cell carcinoma of lung",
          "combined type small cell carcinoma of the lung",
          "combined type small cell lung carcinoma",
          "mixed small cell and large cell carcinoma of lung",
          "mixed small cell and large cell carcinoma of the lung",
          "mixed small cell and large cell lung carcinoma",
          "small cell and large cell carcinoma of lung",
          "small cell and large cell carcinoma of the lung",
          "small cell and large cell lung carcinoma",
          "CSCLC",
          "lung combined type small cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of small cell lung carcinoma in combination with a non-small cell carcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003438"
    }
  ],
  "roots": [
    {
      "id": 2894,
      "label": "small cell carcinoma"
    },
    {
      "id": 6862,
      "label": "lung carcinoma"
    },
    {
      "id": 7117,
      "label": "lung neuroendocrine neoplasm"
    }
  ]
}