{
  "id": 9730,
  "label": "hereditary spastic paraplegia 3A",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008437",
  "properties": {
    "xrefs": [
      "DOID:0110791",
      "GARD:0005041",
      "MEDGEN:419393",
      "MESH:C536864",
      "NCIT:C142893",
      "OMIM:182600",
      "Orphanet:100984",
      "UMLS:C2931355"
    ],
    "synonyms": [
      "ATL1 hereditary spastic paraplegia",
      "FSP1",
      "SPG3A",
      "Strümpell disease",
      "autosomal dominant spastic paraplegia type 3",
      "hereditary spastic paraplegia caused by mutation in ATL1",
      "hereditary spastic paraplegia type 3A",
      "spastic Paraplegia 3A",
      "spastic paraplegia 3a, autosomal dominant",
      "strumpell disease",
      "Spg3",
      "Strumpell disease",
      "familial spastic paraplegia, autosomal dominant, 1",
      "spastic paraplegia 3",
      "spastic paraplegia 3, autosomal dominant"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Any hereditary spastic paraplegia in which the cause of the disease is a mutation in the ATL1 gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18959,
      "label": "hereditary spastic paraplegia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5637,
        21292,
        24271
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2476",
          "GARD:0006637",
          "ICD10CM:G11.4",
          "ICD9:334.1",
          "MEDGEN:20844",
          "MESH:D015419",
          "MedDRA:10019903",
          "NANDO:1200052",
          "NCIT:C140267",
          "NORD:1238",
          "OMIMPS:303350",
          "Orphanet:685",
          "SCTID:39912006",
          "UMLS:C0037773",
          "icd11.foundation:810807375"
        ],
        "synonyms": [
          "spastic paraplegia",
          "HSP",
          "SPG",
          "Strümpell-Lorrain disease",
          "familial spastic paraplegia",
          "hereditary spastic paraparesis",
          "FSP",
          "familial spastic paraparesis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia of the lower limbs."
      },
      "child_count": 135,
      "reference_id": "MONDO:0019064"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18959,
      "label": "hereditary spastic paraplegia"
    }
  ]
}