{
  "id": 9854,
  "label": "thyroid cancer, nonmedullary, 1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008567",
  "properties": {
    "xrefs": [
      "GARD:0024632",
      "MEDGEN:1648293",
      "OMIM:188550",
      "UMLS:C4721429"
    ],
    "synonyms": [
      "thyroid cancer, nonmedullary, 1",
      "thyroid cancer, nonmedullary, type 1",
      "NMTC1",
      "familial nonmedullary thyroid cancer, papillary",
      "nonmedullary thyroid carcinoma, papillary",
      "papillary carcinoma of thyroid"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ]
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6803,
      "label": "thyroid gland papillary carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        16290,
        21537
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3969",
          "EFO:0000641",
          "GARD:0024148",
          "HP:0002895",
          "MEDGEN:66773",
          "NCIT:C4035",
          "ONCOTREE:THPA",
          "SCTID:255029007",
          "UMLS:C0238463"
        ],
        "synonyms": [
          "papillary cancer of the thyroid",
          "papillary cancer of the thyroid gland",
          "papillary cancer of thyroid",
          "papillary cancer of thyroid gland",
          "papillary carcinoma of the thyroid",
          "papillary carcinoma of the thyroid gland",
          "papillary carcinoma of thyroid",
          "papillary carcinoma of thyroid gland",
          "papillary thyroid cancer",
          "papillary thyroid carcinoma",
          "papillary thyroid gland carcinoma",
          "thyroid gland papillary cancer",
          "thyroid gland papillary carcinoma",
          "thyroid papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. Radiation exposure is a risk factor and it is the most common malignant thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient countries. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. Microscopically, the diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005075"
    },
    {
      "id": 18106,
      "label": "familial nonmedullary thyroid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021421",
          "MEDGEN:502247",
          "OMIMPS:188550",
          "Orphanet:319494",
          "UMLS:C3501843"
        ],
        "synonyms": [
          "thyroid cancer, nonmedullary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Familial nonmedullary thyroid carcinoma (fNMTC) is a rare non-syndromic form of thyroid cancer characterized by occurrence of thyroid carcinoma (TC) as the primary feature in a familial setting."
      },
      "child_count": 6,
      "reference_id": "MONDO:0017896"
    },
    {
      "id": 24245,
      "label": "NKX2-1 related choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        5714,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027999"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "The NKX2-1 gene is located on chromosome 14 at 14q13.3 and encodes the NK2 homeobox 1 protein, a transcription factor that binds and activates thyroid specific genes. NKX2-1 was first reported in relation to autosomal dominant NKX2-1 related choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction in 1998."
      },
      "child_count": 9,
      "reference_id": "MONDO:0100520"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6803,
      "label": "thyroid gland papillary carcinoma"
    },
    {
      "id": 18106,
      "label": "familial nonmedullary thyroid carcinoma"
    },
    {
      "id": 24245,
      "label": "NKX2-1 related choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction"
    }
  ]
}