{
  "id": 9868,
  "label": "tooth and nail syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008582",
  "properties": {
    "xrefs": [
      "DOID:6678",
      "GARD:0005587",
      "MEDGEN:140809",
      "MESH:C536736",
      "NCIT:C40553",
      "NORD:1777",
      "OMIM:189500",
      "Orphanet:2228",
      "SCTID:400036004",
      "UMLS:C0406735"
    ],
    "synonyms": [
      "HND",
      "Witkop syndrome",
      "hypodontia and nail dysplasia",
      "hypodontia with nail dysplasia",
      "hypodontia-nail dysgenesis syndrome",
      "hypodontia-nail dysplasia",
      "hypoplastic enamel-onycholysis-hypohidrosis syndrome",
      "tooth and nail syndrome",
      "TNS",
      "WITKOP syndrome",
      "dysplasia of nails with hypodontia",
      "ectodermal dysplasia 3, Tooth/nail type",
      "ectodermal dysplasia 3, Witkop type",
      "hypodontia - dysplasia of nails",
      "hypodontia-dysplasia of nails syndrome",
      "nail dysplasia with hypodontia",
      "tooth-and-nail syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Hypodontia-nail dysplasia syndrome is a form of ectodermal dysplasia."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 19138,
      "label": "ectodermal dysplasia syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        20277,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2121",
          "GARD:0006317",
          "ICD9:757.31",
          "MEDGEN:8544",
          "MESH:D004476",
          "MedDRA:10010452",
          "NCIT:C84683",
          "OMIMPS:305100",
          "Orphanet:79373",
          "SCTID:8654005",
          "UMLS:C0013575",
          "icd11.foundation:1156567558"
        ],
        "synonyms": [
          "ectodermal dysplasia",
          "ectodermal dysplasia (select examples)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "The term ''ectodermal dysplasia'' defines a heterogeneous group of heritable disorders of the skin and its appendages characterized by the defective development of two or more ectodermal derivatives, including hair, teeth, nails, sweat glands and their modified structures (i.e. ceruminous, mammary and ciliary glands). The spectrum of clinical manifestations is wide and may include additional manifestations from other ectodermal, mesodermal and endodermal structures."
      },
      "child_count": 360,
      "reference_id": "MONDO:0019287"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 19138,
      "label": "ectodermal dysplasia syndrome"
    }
  ]
}