{
  "id": 9871,
  "label": "HELLP syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008585",
  "properties": {
    "xrefs": [
      "DOID:13133",
      "EFO:0007297",
      "GARD:0008528",
      "ICD10CM:O14.2",
      "MEDGEN:58162",
      "MESH:D017359",
      "MedDRA:10049058",
      "NCIT:C84750",
      "Orphanet:244242",
      "UMLS:C0162739",
      "icd11.foundation:1748922908"
    ],
    "synonyms": [
      "hemolysis, elevated liver enzymes, low platelets in pregnancy",
      "hemolysis-elevated liver enzymes-low platelet count syndrome",
      "hemolysis-elevated liver enzymes-low platelets syndrome",
      "PEE1",
      "PREECLAMPSIA/eclampsia 1",
      "PREG1",
      "hemolysis, elevated liver enzymes, and low platelet count",
      "hemolysis, elevated liver enzymes, lowered platelets",
      "hypertension, pregnancy-induced",
      "toxaemia of pregnancy",
      "toxemia of pregnancy"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: H emolysis, E levated L iver enzyme levels, and L ow P latelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia. If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby.The main treatment is to deliver the baby as soon as possible, even if premature. Treatment may also include medications needed for the mother or baby, and blood transfusion for severe bleeding problems."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3837,
      "label": "severe pre-eclampsia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6809
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13129",
          "GARD:0022981",
          "ICD10CM:O14.1",
          "ICD9:642.50",
          "MEDGEN:574734",
          "NCIT:C112843",
          "UMLS:C0341950",
          "icd11.foundation:479404771"
        ],
        "synonyms": [
          "Preeclampsia with severe features",
          "severe preeclampsia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances."
      },
      "child_count": 1,
      "reference_id": "MONDO:0001641"
    },
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3837,
      "label": "severe pre-eclampsia"
    },
    {
      "id": 4370,
      "label": "syndromic disease"
    }
  ]
}