{
  "id": 9914,
  "label": "urticaria, aquagenic",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008632",
  "properties": {
    "xrefs": [
      "ICD9:708.8",
      "MEDGEN:82663",
      "MESH:C562481",
      "OMIM:191850",
      "SCTID:89870006",
      "UMLS:C0263334"
    ],
    "synonyms": [
      "Physical urticaria",
      "urticaria, aquagenic",
      "aquagenic urticaria"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "Aquagenic urticaria is a rare condition in which urticaria (hives) develop rapidly after the skin comes in contact with water, regardless of its temperature. It most commonly affects women and symptoms often start around the onset of puberty. Some patients report itching too. It is a form of physical urticaria . The exact underlying cause of aquagenic urticaria is currently unknown. Due to the rarity of the condition, there is very limited data regarding the effectiveness of individual treatments; however, various medications and therapies have been used with variable success."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7148,
      "label": "urticaria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4496
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1555",
          "EFO:0005531",
          "HP:0001025",
          "ICD10CM:L50",
          "ICD10WHO:L50",
          "ICD9:708",
          "ICD9:708.8",
          "ICD9:708.9",
          "MEDGEN:22587",
          "MESH:D014581",
          "NCIT:C3432",
          "SCTID:126485001",
          "UMLS:C0042109"
        ],
        "synonyms": [
          "hives",
          "urticaria",
          "urticaria (disease)",
          "Urticarias"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005492"
    },
    {
      "id": 23867,
      "label": "hereditary skin disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MESH:D012873",
          "SCTID:239001006"
        ],
        "synonyms": [
          "disease, genetic skin",
          "diseases, genetic skin",
          "genetic skin disease",
          "genetic skin diseases",
          "genodermatosis",
          "skin disease, genetic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An instance of skin disease that is caused by a modification of the individual's genome."
      },
      "child_count": 228,
      "reference_id": "MONDO:0100118"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7148,
      "label": "urticaria"
    },
    {
      "id": 23867,
      "label": "hereditary skin disorder"
    }
  ]
}