{
  "id": 9970,
  "label": "acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008696",
  "properties": {
    "xrefs": [
      "GARD:0000453",
      "MEDGEN:348051",
      "MESH:C536000",
      "OMIM:200170",
      "Orphanet:90301",
      "UMLS:C1860215"
    ],
    "synonyms": [
      "acanthosis nigricans muscle cramps acral enlargement",
      "acanthosis nigricans with muscle cramps and acral enlargement",
      "familial insulin resistance with acanthosis nigricans, acral hypertrophy and muscle cramps"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "This syndrome is characterized by the association of acanthosis nigricans, insulin resistance, severe muscle cramps and acral hypertrophy."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 8454,
      "label": "acanthosis nigricans",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4496
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3138",
          "EFO:1000660",
          "HP:0000956",
          "ICD10CM:L83",
          "ICD10WHO:L83",
          "MEDGEN:54",
          "MESH:D000052",
          "NCIT:C26687",
          "Orphanet:924",
          "SCTID:402599005",
          "UMLS:C0000889",
          "Wikipedia:Acanthosis_nigricans",
          "icd11.foundation:71488193"
        ],
        "synonyms": [
          "acanthosis nigricans",
          "acanthosis nigricans (disease)",
          "an - acanthosis nigricans"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A melanotic cutaneous lesion that develops in the axilla and other body folds. It may be idiopathic, drug-induced, or it may be associated with the presence of an endocrine disorder or malignancy."
      },
      "child_count": 2,
      "reference_id": "MONDO:0007035"
    },
    {
      "id": 19129,
      "label": "epidermal disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842776",
          "Orphanet:79353",
          "UMLS:C5681492"
        ],
        "synonyms": [
          "epidermal disease",
          "rare epidermal disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A skin disease that involves the epidermis."
      },
      "child_count": 25,
      "reference_id": "MONDO:0019268"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 8454,
      "label": "acanthosis nigricans"
    },
    {
      "id": 19129,
      "label": "epidermal disease"
    }
  ]
}