{
  "id": 10235,
  "label": "chondrosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008977",
  "properties": {
    "xrefs": [
      "DOID:3371",
      "EFO:0000333",
      "GARD:0006055",
      "HP:0006765",
      "ICD9:170.9",
      "ICDO:9220/3",
      "MEDGEN:3054",
      "MESH:D002813",
      "MedDRA:10008734",
      "NANDO:2200050",
      "NCIT:C2946",
      "OMIM:215300",
      "ONCOTREE:CHS",
      "Orphanet:55880",
      "SCTID:443520009",
      "UMLS:C0008479"
    ],
    "synonyms": [
      "chondrosarcoma",
      "chondrosarcoma (disease)",
      "chondrosarcoma, malignant",
      "chondrosarcoma, somatic mutation",
      "chondrosarcoma of bone",
      "primary chondrosarcoma of the bone"
    ],
    "categories": [
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6816,
      "label": "sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1115",
          "EFO:0000691",
          "ICD9:171",
          "ICD9:171.0",
          "ICD9:171.2",
          "ICD9:171.3",
          "ICD9:171.4",
          "ICD9:171.5",
          "ICD9:171.6",
          "ICD9:171.7",
          "ICD9:171.8",
          "ICD9:171.9",
          "ICDO:8800/3",
          "MEDGEN:224714",
          "MESH:D012509",
          "NCIT:C9118",
          "SCTID:424413001",
          "UMLS:C1261473"
        ],
        "synonyms": [
          "mesenchymal tumor, malignant",
          "sarcoma",
          "sarcoma of soft tissue and bone",
          "sarcoma of the soft tissue and bone",
          "sarcoma, malignant",
          "tumor of soft tissue and skeleton",
          "tumour of soft tissue and skeleton"
        ],
        "definition": "A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005089"
    },
    {
      "id": 20678,
      "label": "connective tissue neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5762,
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:239.2",
          "MEDGEN:45035",
          "MESH:D009372",
          "SCTID:126598008",
          "UMLS:C0027656"
        ],
        "synonyms": [
          "connective tissue neoplasm",
          "connective tissue neoplasm (disease)",
          "connective tissue tumor",
          "connective tissue tumour",
          "neoplasm of connective tissue",
          "neoplasm of connective tissues",
          "tumor of connective tissue",
          "tumour of connective tissue",
          "connective tissue neoplasms",
          "neoplasm, connective tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue."
      },
      "child_count": 26,
      "reference_id": "MONDO:0021581"
    },
    {
      "id": 21247,
      "label": "hereditary disorder of connective tissue",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        5762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:473110",
          "NCIT:C97075",
          "SCTID:363045008",
          "UMLS:C0410787"
        ],
        "synonyms": [
          "Mendelian connective tissue disorder",
          "connective tissue hereditary disorder",
          "hereditary connective tissue disorder",
          "Hereditary Connective Tissue Disorder",
          "Inherited disorder of connective tissue",
          "inherited disorder of connective tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An inherited genetic disorder that affects the connective tissues. Representative examples include Ehlers-Danlos syndrome and Marfan syndrome."
      },
      "child_count": 176,
      "reference_id": "MONDO:0023603"
    }
  ],
  "children": [
    {
      "id": 2966,
      "label": "bone chondrosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        10235
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050897",
          "GARD:0022784",
          "MEDGEN:756255",
          "UMLS:C3163843"
        ],
        "synonyms": [
          "bone tissue chondrosarcoma (disease)",
          "chondrosarcoma (disease) of bone tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A chondrosarcoma (disease) that involves the bone tissue."
      },
      "child_count": 6,
      "reference_id": "MONDO:0000515"
    },
    {
      "id": 5566,
      "label": "myxoid chondrosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        10235
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5861",
          "GARD:0023615",
          "ICDO:9231/3",
          "MEDGEN:87262",
          "NCIT:C4303",
          "ONCOTREE:MYCHS",
          "UMLS:C0334551"
        ],
        "synonyms": [
          "MYCHS"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A chondrosarcoma characterized by the presence of myxoid changes."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003681"
    },
    {
      "id": 5567,
      "label": "localized chondrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10235
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5862",
          "GARD:0023616",
          "MEDGEN:163180",
          "NCIT:C8778",
          "UMLS:C0855011"
        ],
        "synonyms": [
          "chondrosarcoma, localised",
          "chondrosarcoma, localized",
          "localized chondrosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A non-disseminated skeletal or extraskeletal chondrosarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003682"
    },
    {
      "id": 8296,
      "label": "mesenchymal chondrosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8399,
        10235
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4545",
          "EFO:1001041",
          "GARD:0024490",
          "ICDO:9240/3",
          "MEDGEN:104904",
          "MESH:D018211",
          "MedDRA:10027389",
          "NCIT:C3737",
          "ONCOTREE:MCHS",
          "UMLS:C0206637"
        ],
        "synonyms": [
          "mesenchymal chondrosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A morphologic variant of chondrosarcoma arising from bone and soft tissue. It is characterized by the presence of malignant small round cells, biphasic growth pattern, and well differentiated hyaline cartilage. Clinical presentation includes pain and swelling. The clinical course is aggressive, with local recurrences and distant metastases."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006853"
    }
  ],
  "roots": [
    {
      "id": 6816,
      "label": "sarcoma"
    },
    {
      "id": 20678,
      "label": "connective tissue neoplasm"
    },
    {
      "id": 21247,
      "label": "hereditary disorder of connective tissue"
    }
  ]
}