{
  "id": 10236,
  "label": "chordoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0008978",
  "properties": {
    "xrefs": [
      "DOID:3302",
      "GARD:0001303",
      "HP:0010762",
      "ICDO:9370/3",
      "MEDGEN:40277",
      "MESH:D002817",
      "MedDRA:10008747",
      "NANDO:2200098",
      "NCIT:C2947",
      "NORD:931",
      "OMIM:215400",
      "ONCOTREE:CHDM",
      "Orphanet:178",
      "UMLS:C0008487",
      "icd11.foundation:898231522"
    ],
    "synonyms": [
      "chordoma",
      "chordoma (disease)",
      "chordoma, malignant",
      "notochordal sarcoma",
      "CHDM",
      "chordoma, susceptibility to",
      "susceptibility to chordoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "Chordomas are rare malignant tumors arising from embryonic remnants of the notochord in axial skeleton."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4653,
      "label": "notochordal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7212,
        18958
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3303",
          "GARD:0023181",
          "MEDGEN:233252",
          "NCIT:C7063",
          "UMLS:C1335069"
        ],
        "synonyms": [
          "cancer of notochord",
          "malignant neoplasm of notochord",
          "malignant notochord neoplasm",
          "neoplasm of notochord",
          "notochord cancer",
          "notochord neoplasm",
          "notochord tumor",
          "notochord tumour",
          "notochordal neoplasm",
          "notochordal tumor",
          "tumor of notochord",
          "tumour of notochord",
          "notochordal cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A bone tumor arising from the remnants of the fetal notochord. This category includes the chordoma and benign notochordal cell tumor."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002597"
    }
  ],
  "children": [
    {
      "id": 4903,
      "label": "skull base chordoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4265,
        4813,
        10236
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4151",
          "GARD:0023290",
          "MEDGEN:233448",
          "NCIT:C5453",
          "UMLS:C1335975"
        ],
        "synonyms": [
          "chordoma of skull base",
          "chordoma of the skull base",
          "skull base chordoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A slow-growing malignant bone tumor arising from the remnants of the notochord and occurring in the base of the skull. It is characterized by a lobulated growth pattern, myxoid stroma formation, and the presence of physaliphorous cells.."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002892"
    },
    {
      "id": 4904,
      "label": "spinal chordoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        10236
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4153",
          "EFO:1000543",
          "GARD:0023291",
          "MEDGEN:347800",
          "NCIT:C5156",
          "UMLS:C1859101"
        ],
        "synonyms": [
          "chordoma of spinal column",
          "chordoma of spine",
          "chordoma of the spinal column",
          "spinal Chordomas",
          "spinal chordoma",
          "spinal column chordoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A slow-growing malignant bone tumor arising from the remnants of the notochord and occurring in the spine. It is characterized by a lobulated growth pattern, myxoid stroma formation, and the presence of physaliphorous cells."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002894"
    },
    {
      "id": 7708,
      "label": "chondroid chordoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        10236
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4152",
          "EFO:1000174",
          "GARD:0024310",
          "ICDO:9371/3",
          "MEDGEN:224768",
          "NCIT:C6902",
          "UMLS:C1266173"
        ],
        "synonyms": [
          "chondroid chordoma",
          "chondroid chordoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A slow-growing malignant bone tumor arising from the remnants of the notochord and occurring in the base of the skull. The tumor is characterized by a lobulated growth pattern, myxoid stroma formation, and the presence of physaliphorous cells and cartilage."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006145"
    },
    {
      "id": 25846,
      "label": "poorly differentiated chordoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10236
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081417",
          "GARD:0026950",
          "MEDGEN:1791171",
          "NCIT:C177898",
          "UMLS:C5554730"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A chordoma that is characterized by loss of SMARCB1 expression and that is composed of sheets or nests of malignant epithelioid cells with abundant eosinophilic cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0958164"
    }
  ],
  "roots": [
    {
      "id": 4653,
      "label": "notochordal tumor"
    }
  ]
}