{
  "id": 10301,
  "label": "Cushing disease due to pituitary adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009050",
  "properties": {
    "xrefs": [
      "DOID:7004",
      "GARD:0012867",
      "MEDGEN:66381",
      "MESH:D049913",
      "MedDRA:10035109",
      "NANDO:1200379",
      "NANDO:2200350",
      "NCIT:C113210",
      "OMIM:219090",
      "Orphanet:96253",
      "SCTID:254958004",
      "UMLS:C0221406",
      "icd11.foundation:380861892"
    ],
    "synonyms": [
      "ACTH producing pituitary adenoma",
      "Cushing disease",
      "Cushing disease, pituitary",
      "Cushing's disease",
      "PITA4",
      "corticotroph pituitary adenoma",
      "pituitary adenoma 4, ACTH-secreting",
      "pituitary adenoma 4, ACTH-secreting, somatic",
      "pituitary adenoma, ACTH-secreting",
      "pituitary corticotroph micro-adenoma",
      "pituitary dependent Cushing syndrome",
      "pituitary-dependent Cushing syndrome",
      "ACTH-secreting pituitary adenoma",
      "Corticotropinoma",
      "corticotroph adenoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A form of adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome, an endogenous Cushing syndrome (CS), characterized by chronic over-secretion of adrenocorticotropic hormone (ACTH) due to a pituitary corticotroph adenoma."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5357,
      "label": "functioning pituitary gland adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5498,
        7896
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5395",
          "GARD:0021389",
          "MEDGEN:163135",
          "NCIT:C8388",
          "Orphanet:314753",
          "UMLS:C0854486"
        ],
        "synonyms": [
          "endocrine active pituitary adenoma",
          "functioning adenoma of pituitary",
          "functioning adenoma of pituitary gland",
          "functioning adenoma of the pituitary",
          "functioning adenoma of the pituitary gland",
          "functioning pituitary adenoma",
          "functioning pituitary gland adenoma",
          "functioning pituitary gland adenoma (benign)",
          "secreting pituitary adenoma",
          "secretory adenoma of pituitary",
          "secretory adenoma of pituitary gland",
          "secretory adenoma of the pituitary",
          "secretory adenoma of the pituitary gland",
          "secretory pituitary adenoma",
          "secretory pituitary gland adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hormone producing pituitary gland adenoma, associated with a hormonal syndrome."
      },
      "child_count": 10,
      "reference_id": "MONDO:0003429"
    },
    {
      "id": 18043,
      "label": "familial isolated pituitary adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7896,
        21247,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010959",
          "MEDGEN:436629",
          "OMIMPS:102200",
          "Orphanet:314777",
          "SCTID:702375004",
          "UMLS:C2676191"
        ],
        "synonyms": [
          "FIPA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 18,
      "reference_id": "MONDO:0017824"
    },
    {
      "id": 19975,
      "label": "ACTH-dependent Cushing syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8241,
        25672
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3946",
          "EFO:1001110",
          "GARD:0019699",
          "ICD10CM:E24.0",
          "MEDGEN:575036",
          "MESH:D047748",
          "MedDRA:10035109",
          "Orphanet:99892",
          "SCTID:190502001",
          "SCTID:237734007",
          "UMLS:C0342442",
          "icd11.foundation:212778081"
        ],
        "synonyms": [
          "ACTH-dependent CS",
          "adrenocorticotropic hormone-dependent Cushing syndrome",
          "corticotropin-dependent Cushing syndrome",
          "pituitary-dependent Cushing's disease",
          "ACTH hypersecretion, pituitary",
          "adrenocorticotropic hormone, inappropriate secretion",
          "pituitary Cushing disease",
          "pituitary Cushing diseases",
          "pituitary Cushing syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A group of endogenous Cushing syndrome caused by abnormal production of ACTH due to pituitary adenoma or an extrapituitary tumor."
      },
      "child_count": 4,
      "reference_id": "MONDO:0020528"
    },
    {
      "id": 20437,
      "label": "adrenal gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        7151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003850",
          "GARD:0019765",
          "MEDGEN:1352",
          "NCIT:C2859",
          "ONCOTREE:ADRENAL_GLAND",
          "Orphanet:100091",
          "UMLS:C0001624"
        ],
        "synonyms": [
          "adrenal gland neoplasm (disease)",
          "adrenal gland tumor",
          "adrenal gland tumour",
          "adrenal neoplasm",
          "adrenal neoplasms",
          "adrenal tumor",
          "adrenal tumour",
          "neoplasm of adrenal gland",
          "neoplasm of the adrenal gland",
          "tumor of adrenal gland",
          "tumor of the adrenal gland",
          "tumour of adrenal gland",
          "tumour of the adrenal gland",
          "ADRENAL_GLAND",
          "adrenal/paraganglial tumor",
          "adrenal/paraganglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the adrenal gland."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021227"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5357,
      "label": "functioning pituitary gland adenoma"
    },
    {
      "id": 18043,
      "label": "familial isolated pituitary adenoma"
    },
    {
      "id": 19975,
      "label": "ACTH-dependent Cushing syndrome"
    },
    {
      "id": 20437,
      "label": "adrenal gland neoplasm"
    }
  ]
}