{
  "id": 10348,
  "label": "Wolfram syndrome 1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009101",
  "properties": {
    "xrefs": [
      "DOID:0110629",
      "GARD:0024648",
      "MEDGEN:1641635",
      "OMIM:222300",
      "UMLS:C4551693"
    ],
    "synonyms": [
      "WFS1",
      "WFS1 Wolfram syndrome",
      "Wolfram syndrome 1",
      "Wolfram syndrome caused by mutation in WFS1",
      "Wolfram syndrome type 1",
      "WOLFRAM syndrome 1",
      "Wfs",
      "diabetes insipidus and mellitus with optic atrophy and deafness"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Any Wolfram syndrome in which the cause of the disease is a mutation in the WFS1 gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18263,
      "label": "Wolfram syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10632",
          "GARD:0007898",
          "ICD9:250.80",
          "MEDGEN:21923",
          "MESH:D014929",
          "NANDO:1200757",
          "NCIT:C35133",
          "Orphanet:3463",
          "SCTID:70694009",
          "UMLS:C0043207",
          "icd11.foundation:151381747"
        ],
        "synonyms": [
          "DIDMOAD",
          "DIDMOAD syndrome",
          "Wolfram syndrome",
          "diabetes insipidus, diabetes mellitus, optic atrophy, and deafness syndrome",
          "diabetes insipidus-diabetes mellitus-optic atrophy-deafness syndrome",
          "diabetes mellitus and insipidus with optic atrophy and deafness"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Wolfram syndrome (WS) also known as DIDMOAD, is a neurodegenerative disorder characterized by type I diabetes mellitus (DM), diabetes insipidus (DI), sensorineural deafness (D), bilateral optical atrophy (OA) and neurological signs. Other related problems are urinary tract atony, ataxia, peripheral neuropathy, psychiatric disorders and/or seizures. 2 types of WS may be distinguished: type 1 and type 2 (WS1 and WS2)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0018105"
    },
    {
      "id": 24687,
      "label": "WFS1-related disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028010"
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0700293"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18263,
      "label": "Wolfram syndrome"
    },
    {
      "id": 24687,
      "label": "WFS1-related disorder"
    }
  ]
}