{
  "id": 10467,
  "label": "fetal iodine syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009224",
  "properties": {
    "xrefs": [
      "GARD:0002304",
      "MEDGEN:907922",
      "OMIM:228355",
      "Orphanet:1910",
      "SCTID:718228001",
      "UMLS:C4273860"
    ],
    "synonyms": [
      "FIDD",
      "endemic cretinism",
      "fetal iodine deficiency disorder",
      "foetal iodine deficiency disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Fetal iodine syndrome refers to symptoms and signs that may be observed in a fetus or newborn when the mother was exposed during pregnancy to inappropriate (insufficient or excessive) amounts of iodine. Iodine deficiency is associated with goiter and hypothyroidism. When severe iodine deficiency occurs during pregnancy, it is associated with congenital hypothyroidism that is manifested by increased neonatal morbi-mortality and severe mental dysfunction, hyperactivity, attention disorders and a substantial decrease of IQ of an irreversible nature. Excessive iodine ingestion during the third trimester of pregnancy can result in hypothyroidism and fetal goiter due to a prolonged inhibition of thyroid hormone synthesis, an increase in thyrotropin (TSH)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17050,
      "label": "transient congenital hypothyroidism due to maternal factor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020645",
          "MEDGEN:1842783",
          "Orphanet:238696",
          "UMLS:C5680929"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0016555"
    },
    {
      "id": 17143,
      "label": "toxic or drug-related embryofetopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19507
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1843068",
          "MESH:D000014",
          "Orphanet:251529",
          "UMLS:C5680710",
          "icd11.foundation:293076727"
        ],
        "definition": "Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment."
      },
      "child_count": 22,
      "reference_id": "MONDO:0016677"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17050,
      "label": "transient congenital hypothyroidism due to maternal factor"
    },
    {
      "id": 17143,
      "label": "toxic or drug-related embryofetopathy"
    }
  ]
}