{
  "id": 10580,
  "label": "classic Hodgkin lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009348",
  "properties": {
    "xrefs": [
      "GARD:0016529",
      "MEDGEN:9283",
      "NCIT:C7164",
      "OMIM:236000",
      "ONCOTREE:CHL",
      "Orphanet:391",
      "UMLS:C0019829",
      "icd11.foundation:1616050398"
    ],
    "synonyms": [
      "classic Hodgkin disease",
      "classical Hodgkin lymphoma",
      "classical Hodgkin's lymphoma",
      "Chl",
      "Hodgkin disease",
      "Hodgkin lymphoma, susceptibility to",
      "lymphoma, Hodgkin, classic"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Classical Hodgkin lymphoma (CHL) is a B-cell lymphoma characterized histologically by the presence of large mononuclear Hodgkin cells and multinucleated Reed-Sternberg (HRS) cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 6697,
      "label": "Hodgkins lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6792,
        17660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8567",
          "EFO:0000183",
          "GARD:0002714",
          "ICD10CM:C81",
          "ICD9:201",
          "ICD9:201.0",
          "ICD9:201.1",
          "ICD9:201.2",
          "ICD9:201.9",
          "ICD9:201.90",
          "ICDO:9650/3",
          "MESH:D006689",
          "NANDO:2200024",
          "NCIT:C9357",
          "NORD:1246",
          "ONCOTREE:HL",
          "Orphanet:98293",
          "icd11.foundation:1528863768"
        ],
        "synonyms": [
          "HL",
          "Hodgkin disease",
          "Hodgkin lymphoma",
          "Hodgkin's Disease",
          "Hodgkin's disease",
          "Hodgkin's lymphoma",
          "stage I subdiaphragmatic Hodgkin lymphoma",
          "stage II subdiaphragmatic Hodgkin lymphoma",
          "Hodgkin's sarcoma",
          "lymphoma, Hodgkin's"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A heterogeneous group of malignant lymphoid neoplasms of B-cell origin characterized histologically by the presence of Hodgkin and Reed-Sternberg (HRS) cells in the vast majority of cases. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004952"
    }
  ],
  "children": [
    {
      "id": 6395,
      "label": "Hodgkin's lymphoma, lymphocytic-histiocytic predominance",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10580
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8543",
          "GARD:0019593",
          "ICD9:201.4",
          "ICDO:9651/3",
          "MEDGEN:224769",
          "MedDRA:10020231",
          "NCIT:C6913",
          "ONCOTREE:LRCHL",
          "Orphanet:98845",
          "SCTID:118607005",
          "UMLS:C1266194",
          "icd11.foundation:352299041"
        ],
        "synonyms": [
          "Hodgkin lymphoma, lymphocyte-rich",
          "Hodgkin's disease, lymphocyte predominance [obs]",
          "LRCHL",
          "classic Hodgkin lymphoma, lymphocyte-rich type",
          "lymphocyte rich Hodgkin lymphoma",
          "lymphocyte rich Hodgkin's disease",
          "lymphocyte rich Hodgkin's lymphoma",
          "lymphocyte rich classical Hodgkin lymphoma",
          "lymphocyte rich classical Hodgkin's disease",
          "lymphocyte rich classical Hodgkin's lymphoma",
          "lymphocyte-rich Classic Hodgkin lymphoma",
          "lymphocyte-rich classical Hodgkin lymphoma",
          "lymphocyte-rich classical Hodgkin's lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A subtype of classical Hodgkin lymphoma with scattered Hodgkin and Reed-Sternberg cells and a nodular or less often diffuse cellular background consisting of small lymphocytes and with an absence of neutrophils and eosinophils. (WHO, 2008)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004604"
    },
    {
      "id": 6409,
      "label": "Hodgkin's lymphoma, lymphocytic depletion",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10580
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8628",
          "GARD:0019594",
          "ICD9:201.7",
          "MEDGEN:57760",
          "NCIT:C9125",
          "ONCOTREE:LDCHL",
          "Orphanet:98846",
          "SCTID:118610003",
          "UMLS:C0152267",
          "icd11.foundation:1729182645"
        ],
        "synonyms": [
          "Adult lymphocyte-depleted Classic Hodgkin lymphoma",
          "Hodgkin lymphoma, lymphocyte depletion",
          "Hodgkin's disease, lymphocytic depletion NOS (morphologic abnormality)",
          "Hodgkin's disease, lymphocytic depletion, unspecified site, extranodal and solid organ sites",
          "adult HDLD",
          "adult LDHD",
          "adult lymphocyte depleted Hodgkin lymphoma",
          "adult lymphocyte depleted Hodgkin's lymphoma",
          "adult lymphocyte depleted classical Hodgkin lymphoma",
          "adult lymphocyte depletion Hodgkin's disease",
          "adult lymphocyte-depleted classical Hodgkin lymphoma",
          "classic Hodgkin lymphoma, lymphocyte-depleted type",
          "lymphocyte-depleted classical Hodgkin lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A diffuse subtype of classical Hodgkin lymphoma which is rich in Hodgkin and Reed-Sternberg cells and/or depleted in non-neoplastic lymphocytes. (WHO, 2008)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004620"
    },
    {
      "id": 6419,
      "label": "Hodgkin's lymphoma, mixed cellularity",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10580
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8654",
          "EFO:1002031",
          "GARD:0019592",
          "ICD10CM:C81.2",
          "ICD9:201.6",
          "ICDO:9652/3",
          "MEDGEN:57521",
          "NCIT:C3517",
          "ONCOTREE:MCCHL",
          "Orphanet:98844",
          "SCTID:118609008",
          "UMLS:C0152266",
          "icd11.foundation:39515681"
        ],
        "synonyms": [
          "Hodgkin lymphoma, mixed cellularity",
          "Hodgkin's disease mixed cellularity",
          "Hodgkin's disease, mixed cellularity of unspecified site",
          "Hodgkin's lymphoma mixed cellularity",
          "MCCHL",
          "MCHL",
          "Mixed cellularity Classic Hodgkin lymphoma",
          "classic Hodgkin lymphoma, mixed cellularity type",
          "mixed cellularity Hodgkin lymphoma",
          "mixed cellularity Hodgkin's disease",
          "mixed cellularity Hodgkin's lymphoma",
          "mixed cellularity classical Hodgkin lymphoma",
          "Hodgkin's disease, mixed cellularity"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A subtype of classical Hodgkin lymphoma with scattered Reed-Sternberg and Hodgkin cells in a diffuse or vaguely nodular mixed inflammatory background without nodular sclerosing fibrosis. (WHO, 2008)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004633"
    },
    {
      "id": 6449,
      "label": "nodular sclerosis classical Hodgkin lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10580
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8838",
          "EFO:0004708",
          "GARD:0019591",
          "ICD10CM:C81.1",
          "ICD9:201.5",
          "ICDO:9663/3",
          "MEDGEN:101830",
          "NCIT:C3518",
          "ONCOTREE:NSCHL",
          "Orphanet:98843",
          "SCTID:118608000",
          "UMLS:C0152268",
          "icd11.foundation:1995941600"
        ],
        "synonyms": [
          "Hodgkin lymphoma, nodular sclerosis",
          "Hodgkin's disease nodular sclerosis",
          "Hodgkin's disease, nodular sclerosis NOS (morphologic abnormality)",
          "Hodgkin's disease, nodular sclerosis of unspecified site",
          "Hodgkin's nodular sclerosis",
          "NSCHL",
          "NSHD",
          "NSHL",
          "nodular sclerosis Classic Hodgkin lymphoma",
          "nodular sclerosis Hodgkin lymphoma",
          "nodular sclerosis Hodgkin's disease",
          "nodular sclerosis Hodgkin's lymphoma",
          "nodular sclerosis classical Hodgkin lymphoma",
          "Hodgkin's disease, nodular sclerosis",
          "Hodgkin's lymphoma, nodular sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A subtype of classical Hodgkin lymphoma characterized by collagen bands that surround at least one nodule, and Hodgkin and Reed-Sternberg cells with lacunar type morphology. (WHO, 2008)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004665"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 6697,
      "label": "Hodgkins lymphoma"
    }
  ]
}