{
  "id": 10688,
  "label": "spermatogenic failure 5",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009461",
  "properties": {
    "xrefs": [
      "DOID:0070183",
      "GARD:0012385",
      "MEDGEN:98020",
      "MESH:C562903",
      "OMIM:243060",
      "Orphanet:137893",
      "SCTID:236806004",
      "UMLS:C0403812"
    ],
    "synonyms": [
      "SPGF5",
      "macrocephalic sperm head syndrome",
      "macrozoospermia with multiflagellar polyploid spermatozoa",
      "male infertility due to large-headed multiflagellar polyploid spermatozoa",
      "male infertility due to macrozoospermia",
      "male infertility with large-headed, multiflagellar, polyploid spermatozoa",
      "spermatogenic failure 5",
      "spermatogenic failure type 5",
      "macrozoospermia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A male infertility due to sperm disorder characterized by the presence, in sperm, of a very high percentage of spermatozoa with enlarged head, irregular head shape, multiple flagella, and abnormal midpiece and acrosome. It is generally associated with severe oligoasthenozoospermia and a high rate of sperm chromosomal abnormalities (polyploidy, aneuploidy)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6724,
      "label": "spermatogenic failure",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7053
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111910",
          "EFO:0000279",
          "MEDGEN:766708",
          "OMIMPS:258150",
          "UMLS:C3553794"
        ],
        "synonyms": [
          "spermatogenic failure"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A male infertility characterized by dirsuption of the process of sperm development from diploid cells into mature haploid spermatozoa."
      },
      "child_count": 226,
      "reference_id": "MONDO:0004983"
    },
    {
      "id": 18463,
      "label": "male infertility with teratozoospermia due to single gene mutation",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7053
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017654",
          "MEDGEN:1643966",
          "Orphanet:399808",
          "SCTID:764096006",
          "UMLS:C4706677"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare, genetic male infertility due to sperm disorder characterized by the presence of spermatozoa with abnormal morphology, such as macrozoospermia or globozoospermia, in over 85% of sperm, resulting from mutation in a single gene known to cause teratozoospermia. It is a heterogeneous group that includes a wide range of abnormal sperm phenotypes affecting, solely or simultaneously, head, neck, midpiece, and/or tail."
      },
      "child_count": 3,
      "reference_id": "MONDO:0018394"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6724,
      "label": "spermatogenic failure"
    },
    {
      "id": 18463,
      "label": "male infertility with teratozoospermia due to single gene mutation"
    }
  ]
}