{
  "id": 10699,
  "label": "isotretinoin-like syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009473",
  "properties": {
    "xrefs": [
      "GARD:0009675",
      "MEDGEN:96600",
      "MESH:C535542",
      "OMIM:243440",
      "Orphanet:2306",
      "SCTID:722006004",
      "UMLS:C0432364"
    ],
    "synonyms": [
      "Kawashima syndrome",
      "microtia-aortic arch syndrome",
      "ISOTRETINOIN embryopathy-like syndrome",
      "Isotretinoin embryopathy like syndrome",
      "microtia aortic arch syndrome",
      "microtia-aortic Arch syndrome",
      "syndrome of microtia and aortic arch anomalies"
    ],
    "definition": "Isotretinoin-like syndrome is a phenocopy of the isotretinoin embryopathy."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 16088,
      "label": "multiple congenital anomalies/dysmorphic syndrome-variable intellectual disability syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18951
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025062",
          "Orphanet:102284"
        ],
        "synonyms": [
          "MCA/variable MR",
          "multiple congenital anomalies-variable intellectual disability with or without dysmorphism syndrome"
        ]
      },
      "child_count": 69,
      "reference_id": "MONDO:0015160"
    }
  ],
  "children": [
    {
      "id": 16977,
      "label": "isotretinoin syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        10699,
        17143
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:419683",
          "MESH:C535670",
          "NCIT:C98929",
          "NORD:1140",
          "Orphanet:2305",
          "SCTID:36871005",
          "UMLS:C2930972"
        ],
        "synonyms": [
          "Fetal Retinoid Syndrome",
          "Isotretinoin embryopathy",
          "Retinoids embryopathy",
          "fetal isotretinoin syndrome",
          "fetal retinoid syndrome",
          "foetal isotretinoin syndrome",
          "foetal retinoid syndrome",
          "retinoic acid embryopathy",
          "Accutane fetal effects of",
          "Accutane foetal effects of",
          "Accutane-exposed pregnancies",
          "Acutane embryopathy",
          "Isotretinoin (RoAccutane) embryopathy",
          "Isotretinoin fetal effects of",
          "Isotretinoin foetal effects of",
          "Isotretinoin teratogen syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Isotretinoin embryopathy is an association of malformations caused by the teratogenic effect of isotretinoin, an oral synthetic vitamin A derivative, which is used to treat severe recalcitrant cystic acne. Exposure to isotretinoin during the first trimester of pregnancy has been associated with an increased risk of spontaneous abortions and severe birth defects including serious craniofacial (microcephaly, asymmetric crying facies, microphthalmia, developmental abnormalities of the external ear, ocular hypertelorism), cardio vascular (conotruncal heart defects, aortic arch abnormalities), and central nervous system (hydrocephalus, microcephaly, lissencephaly, Dandy-Walker malformation, cognitive deficit) anomalies and thymic aplasia. Isoretinoin is contraindicated during pregnancy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016467"
    }
  ],
  "roots": [
    {
      "id": 16088,
      "label": "multiple congenital anomalies/dysmorphic syndrome-variable intellectual disability syndrome"
    }
  ]
}