{
  "id": 10734,
  "label": "Landau-Kleffner syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009509",
  "properties": {
    "xrefs": [
      "DOID:2538",
      "EFO:1001010",
      "GARD:0006855",
      "MEDGEN:79465",
      "MESH:D018887",
      "MedDRA:10052075",
      "MedDRA:10052083",
      "NANDO:1200602",
      "NCIT:C84806",
      "Orphanet:98818",
      "SCTID:230438007",
      "UMLS:C0282512",
      "icd11.foundation:348544271"
    ],
    "synonyms": [
      "LKS",
      "Landau-Kleffner syndrome",
      "acquired epileptic aphasia",
      "FESD",
      "Rolandic epilepsy, intellectual disability, and speech dyspraxia, autosomal dominant",
      "Rolandic epilepsy, mental retardation, and speech dyspraxia, autosomal dominant",
      "acquired aphasia with convulsive disorder",
      "acquired epileptiform aphasia",
      "aphasia, acquired, with epilepsy",
      "benign epilepsy of childhood with centrotemporal spikes",
      "continuous Spike and waves during slow-Wave sleep syndrome",
      "epilepsy, focal, with speech disorder and with or without impaired intellectual development",
      "epilepsy, focal, with speech disorder and with or without intellectual disability",
      "epilepsy, focal, with speech disorder and with or without mental retardation"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A rare form of epileptic encephalopathy with spike-wave activation in sleep (EE-SWAS) characterized by various combinations of acquired cognitive, language, behavioral, and motor deficits associated with marked spike- and- wave activation in sleep. In Landau-Kleffner syndrome, receptive language is mainly affected, with an acquired auditory verbal agnosia."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 19725,
      "label": "childhood-onset epilepsy syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16436
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019437",
          "MEDGEN:1843031",
          "Orphanet:98259",
          "UMLS:C5681526"
        ],
        "synonyms": [
          "childhood epilepsy syndrome",
          "childhood-onset epilepsy syndrome",
          "epilepsy syndrome of childhood",
          "paediatric epilepsy syndrome",
          "pediatric epilepsy syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A epilepsy syndrome that occurs during childhood."
      },
      "child_count": 16,
      "reference_id": "MONDO:0020072"
    },
    {
      "id": 29313,
      "label": "GRIN2A-related complex neurodevelopmental disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028157"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of neurological and neurodevelopmental disorders caused by variants in the GRIN2A gene, characterized by a broad spectrum of symptoms including developmental delay or intellectual disability, epilepsy, speech and language impairments, movement disorders, and neuropsychiatric features."
      },
      "child_count": 5,
      "reference_id": "MONDO:1060139"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 19725,
      "label": "childhood-onset epilepsy syndrome"
    },
    {
      "id": 29313,
      "label": "GRIN2A-related complex neurodevelopmental disorder"
    }
  ]
}