{
  "id": 10743,
  "label": "letterer-Siwe disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009519",
  "properties": {
    "xrefs": [
      "GARD:0024676",
      "ICD10CM:C96.0",
      "ICDO:9754/3",
      "MEDGEN:7311",
      "MedDRA:10024265",
      "NCIT:C3160",
      "OMIM:246400",
      "Orphanet:99870",
      "UMLS:C0023381",
      "icd11.foundation:1827474596"
    ],
    "synonyms": [
      "acute and disseminated Langerhans cell histiocytosis",
      "acute disseminated Langerhans cell histiocytosis",
      "letterer-Siwe disease",
      "multifocal multisystem Langerhans cell histiocytosis",
      "L-S disease",
      "histiocytosis X, acute disseminated"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A multifocal, multisystem form of Langerhans-cell histiocytosis. There is involvement of multiple organ systems including the bones, skin, liver, spleen, and lymph nodes. Patients are usually infants presenting with fever, hepatosplenomegaly, lymphadenopathy, bone and skin lesions, and pancytopenia."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17420,
      "label": "Langerhans cell histiocytosis specific to childhood",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18407
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025085",
          "MEDGEN:859249",
          "NANDO:2200031",
          "NCIT:C114483",
          "Orphanet:264724",
          "UMLS:C3899655"
        ],
        "synonyms": [
          "Langerhans cell histiocytosis",
          "Langerhans cell granulomatosis specific to childhood",
          "childhood Langerhans cell histiocytosis",
          "histiocytosis X specific to childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Langerhans cell histiocytosis that occurs during childhood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0017025"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17420,
      "label": "Langerhans cell histiocytosis specific to childhood"
    }
  ]
}