{
  "id": 10902,
  "label": "myasthenia gravis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009688",
  "properties": {
    "xrefs": [
      "DOID:437",
      "EFO:0004991",
      "GARD:0007122",
      "ICD10CM:G70.0",
      "ICD9:358.0",
      "ICD9:358.00",
      "MEDGEN:7764",
      "MESH:D009157",
      "MedDRA:10028417",
      "NANDO:1200020",
      "NANDO:2100252",
      "NANDO:2200906",
      "NCIT:C60989",
      "NORD:1478",
      "OMIM:254200",
      "Orphanet:589",
      "SCTID:91637004",
      "UMLS:C0026896",
      "icd11.foundation:1270100227"
    ],
    "synonyms": [
      "acquired myasthenia",
      "autoimmune myasthenia gravis",
      "myasthenia gravis",
      "MG"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 3006,
      "label": "autoimmune disorder of peripheral nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4981,
        5512
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060033"
        ],
        "synonyms": [
          "peripheral nervous system autoimmune disease",
          "peripheral nervous system hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the peripheral nervous system."
      },
      "child_count": 8,
      "reference_id": "MONDO:0000590"
    }
  ],
  "children": [
    {
      "id": 8308,
      "label": "neonatal myasthenia gravis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10902
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14043",
          "GARD:0024493",
          "ICD9:775.2",
          "MEDGEN:102360",
          "MESH:D020941",
          "MedDRA:10028963",
          "SCTID:82178003",
          "UMLS:C0158982",
          "icd11.foundation:1274860004"
        ],
        "synonyms": [
          "neonatal myasthenia gravis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder of neuromuscular transmission that occurs in a minority of newborns born to women with myasthenia gravis. Clinical features are usually present at birth or develop in the first 3 days of life and consist of hypotonia and impaired respiratory, suck, and swallowing abilities. This condition is associated with the passive transfer of acetylcholine receptor antibodies through the placenta. In the majority of infants the myasthenic weakness resolves (i.e., transient neonatal myasthenia gravis) although this disorder may rarely continue beyond the neonatal period (i.e., persistent neonatal myasthenia gravis). (From Menkes, Textbook of Child Neurology, 5th ed, p823; Neurology 1997 Jan;48(1):50-4)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0006866"
    },
    {
      "id": 9360,
      "label": "myasthenia, limb-girdle, autoimmune",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10902
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008575",
          "MEDGEN:331795",
          "MESH:C563552",
          "OMIM:159400",
          "UMLS:C1834635"
        ],
        "synonyms": [
          "myasthenia, limb-girdle, autoimmune",
          "myasthenia gravis, limb-girdle"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008036"
    },
    {
      "id": 12853,
      "label": "myasthenia gravis with thymus hyperplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10902
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024823",
          "MEDGEN:375982",
          "MESH:C564628",
          "OMIM:607085",
          "UMLS:C1846838"
        ],
        "synonyms": [
          "myasthenia gravis with thymus hyperplasia",
          "Myas1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011768"
    },
    {
      "id": 18419,
      "label": "adult-onset myasthenia gravis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10902
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001490",
          "GARD:0021623",
          "MEDGEN:1843050",
          "Orphanet:391490",
          "UMLS:C5680024"
        ],
        "synonyms": [
          "adult-onset acquired myasthenia",
          "adult-onset autoimmune myasthenia gravis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Acquired myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction characterized by fatigable muscle weakness with frequent ocular signs and/or generalized muscle weakness, and occasionally associated with thymoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018324"
    },
    {
      "id": 18420,
      "label": "juvenile myasthenia gravis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10902
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021624",
          "MEDGEN:1842990",
          "Orphanet:391497",
          "UMLS:C5680023"
        ],
        "synonyms": [
          "childhood myasthenia gravis",
          "juvenile acquired myasthenia",
          "juvenile autoimmune myasthenia gravis",
          "myasthenia gravis of childhood",
          "paediatric myasthenia gravis",
          "pediatric myasthenia gravis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Juvenile myasthenia gravis (MG) is a rare form of MG, an autoimmune disorder of the neuromuscular junction resulting in ocular manifestations or generalized weakness, with onset before 18 years of age."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018325"
    },
    {
      "id": 18421,
      "label": "transient neonatal myasthenia gravis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10902,
        18439
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021625",
          "ICD10CM:P94.0",
          "MEDGEN:96918",
          "NCIT:C117308",
          "Orphanet:391504",
          "UMLS:C0495465",
          "icd11.foundation:2096990223"
        ],
        "synonyms": [
          "neonatal myasthenia gravis",
          "NMG",
          "transient neonatal acquired myasthenia",
          "transient neonatal autoimmune myasthenia gravis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Transient neonatal myasthenia gravis (MG) is a rare form of MG occurring in neonates born to mothers who have the disorder or specific circulating autoantibodies."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018326"
    }
  ],
  "roots": [
    {
      "id": 3006,
      "label": "autoimmune disorder of peripheral nervous system"
    }
  ]
}