{
  "id": 10906,
  "label": "primary myelofibrosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009692",
  "properties": {
    "xrefs": [
      "DOID:4971",
      "EFO:0002430",
      "GARD:0008618",
      "ICD10CM:D47.4",
      "ICD9:238.76",
      "ICD9:289.83",
      "ICDO:9961/3",
      "MEDGEN:7929",
      "MESH:D055728",
      "NCIT:C2862",
      "NORD:1611",
      "OMIM:254450",
      "ONCOTREE:PMF",
      "Orphanet:824",
      "UMLS:C0001815",
      "icd11.foundation:1407285327",
      "icd11.foundation:336704235"
    ],
    "synonyms": [
      "AMM",
      "Agnogenic myeloid metaplasia",
      "CIMF",
      "chronic idiopathic myelofibrosis",
      "idiopathic bone marrow fibrosis",
      "idiopathic myelofibrosis",
      "myelofibrosis with myeloid metaplasia, somatic",
      "myelofibrosis, somatic",
      "myelosclerosis with myeloid metaplasia",
      "osteomyelofibrosis",
      "primary myelofibrosis",
      "myelofibrosis with myeloid metaplasia",
      "myelofibrosis",
      "myeloid metaplasia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 16404,
      "label": "acquired aplastic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16610
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020058",
          "MEDGEN:543648",
          "NANDO:2201277",
          "Orphanet:164823",
          "SCTID:55907008",
          "UMLS:C0271907"
        ],
        "synonyms": [
          "acquired aplastic anemia",
          "rare acquired aplastic anaemia",
          "rare acquired aplastic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An instance of aplastic anemia that is acquired during the lifetime of the individual."
      },
      "child_count": 3,
      "reference_id": "MONDO:0015610"
    },
    {
      "id": 19727,
      "label": "myeloproliferative neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6892,
        16513,
        20376
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2226",
          "EFO:0002428",
          "GARD:0009319",
          "ICD9:238.79",
          "ICDO:9960/3",
          "ICDO:9975/1",
          "MEDGEN:220955",
          "MedDRA:10028576",
          "NCIT:C4345",
          "ONCOTREE:MPN",
          "Orphanet:98274",
          "SCTID:425333006",
          "UMLS:C1292778"
        ],
        "synonyms": [
          "CMPD",
          "MPD",
          "MPN",
          "chronic myeloproliferative disease",
          "chronic myeloproliferative disorder",
          "chronic myeloproliferative neoplasm",
          "myeloproliferative disorder",
          "myeloproliferative neoplasm",
          "myeloproliferative neoplasm, chronic",
          "myeloproliferative tumor",
          "myeloproliferative tumour",
          "CMPD, U",
          "chronic myeloproliferative disorders",
          "myeloproliferative neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)"
      },
      "child_count": 39,
      "reference_id": "MONDO:0020076"
    }
  ],
  "children": [
    {
      "id": 6269,
      "label": "cellular phase chronic idiopathic myelofibrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10906,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8106",
          "GARD:0024019",
          "MEDGEN:275741",
          "NCIT:C41237",
          "ONCOTREE:PMFPES",
          "UMLS:C1516553"
        ],
        "synonyms": [
          "Prefibrotic/Early Primary myelofibrosis",
          "chronic idiopathic myelofibrosis, Prefibrotic stage",
          "chronic idiopathic myelofibrosis, cellular phase",
          "primary myelofibrosis, Prefibrotic stage",
          "primary myelofibrosis, Prefibrotic/early stage",
          "PMFPES"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Primary myelofibrosis characterized by bone marrow hypercellularity and the presence of atypical megakaryocytes. There is no increase in the percentage of myeloblasts and no significant increase in reticulin or collagen fibrosis in the bone marrow."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004463"
    },
    {
      "id": 21141,
      "label": "familial myelofibrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10906
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008516",
          "MEDGEN:444034",
          "MESH:C536848",
          "UMLS:C2931351"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0023119"
    },
    {
      "id": 23149,
      "label": "panostotic fibrous dysplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3155,
        10906
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025857",
          "MEDGEN:419799",
          "MESH:C537164",
          "UMLS:C2931430"
        ],
        "synonyms": [
          "unusual facial appearance, bone fragility, hyperphosphatasemia, and hypophosphatemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0043168"
    },
    {
      "id": 24909,
      "label": "myelofibrosis with myeloid metaplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10906
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026490",
          "icd11.foundation:673220507"
        ],
        "synonyms": [
          "MMM"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0800305"
    }
  ],
  "roots": [
    {
      "id": 16404,
      "label": "acquired aplastic anemia"
    },
    {
      "id": 19727,
      "label": "myeloproliferative neoplasm"
    }
  ]
}