{
  "id": 10907,
  "label": "plasma cell myeloma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009693",
  "properties": {
    "xrefs": [
      "DOID:9538",
      "EFO:0001378",
      "GARD:0007108",
      "ICD10CM:C90.0",
      "ICD9:203.0",
      "ICDO:9732/3",
      "MEDGEN:10122",
      "MESH:D009101",
      "MedDRA:10028228",
      "NCIT:C3242",
      "NORD:1469",
      "OMIM:254500",
      "ONCOTREE:PCM",
      "Orphanet:29073",
      "UMLS:C0026764",
      "icd11.foundation:1582389689",
      "icd11.foundation:526287100"
    ],
    "synonyms": [
      "Kahler disease",
      "Kahler's disease",
      "Multiple Myeloma",
      "medullary plasmacytoma",
      "multiple myeloma",
      "multiple myeloma, resistance to, Somatic mutation",
      "multiple myeloma, susceptibility to, Somatic mutation",
      "multiple myeloma/plasma cell myeloma",
      "myeloid neoplasm of plasma cell",
      "myeloma",
      "myeloma, multiple",
      "myeloma, plasma cell, malignant",
      "myelomatosis",
      "plasma cell myeloid neoplasm",
      "plasma cell myeloma",
      "Al amyloidosis",
      "amyloidosis, systemic",
      "myeloma - multiple"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 3028,
      "label": "immune system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060083"
        ],
        "synonyms": [
          "cancer of immune system",
          "immune system cancer",
          "malignant immune system neoplasm",
          "malignant neoplasm of immune system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the immune system"
      },
      "child_count": 50,
      "reference_id": "MONDO:0000621"
    },
    {
      "id": 6702,
      "label": "plasma cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6536",
          "EFO:0000200",
          "GARD:0019440",
          "ICD9:238.6",
          "MEDGEN:368758",
          "MESH:D054219",
          "NCIT:C4665",
          "Orphanet:98282",
          "SCTID:415111003",
          "UMLS:C1959632"
        ],
        "synonyms": [
          "plasma cell dyscrasia",
          "plasma cell neoplasm",
          "plasma cell tumor",
          "plasma cell tumor, malignant",
          "plasmacytic neoplasm",
          "plasmacytic tumor",
          "plasmacytic tumour",
          "plasma cell disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance."
      },
      "child_count": 7,
      "reference_id": "MONDO:0004959"
    },
    {
      "id": 6892,
      "label": "myeloid neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070004",
          "EFO:0002427",
          "GARD:0024160",
          "ICDO:9975/1",
          "MEDGEN:445430",
          "NCIT:C9290",
          "ONCOTREE:MYELOID",
          "UMLS:C2939461"
        ],
        "synonyms": [
          "myeloid malignancy",
          "myeloid neoplasm",
          "myeloid tumor",
          "myeloid tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Proliferation of myeloid cells originating from a primitive stem cell."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005170"
    }
  ],
  "children": [
    {
      "id": 6576,
      "label": "osteosclerotic plasma cell myeloma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10907
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9541",
          "GARD:0024111",
          "MEDGEN:857662",
          "NCIT:C7765",
          "SCTID:425657001",
          "UMLS:C3898068"
        ],
        "synonyms": [
          "osteosclerotic multiple myeloma",
          "osteosclerotic plasma cell myeloma",
          "osteosclerotic myeloma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A plasma cell neoplasm associated with osteosclerotic and fibrotic changes in the bone trabeculae. Often, the lymph nodes show changes resembling the plasma cell variant of Castleman disease. It is often part of POEMS syndrome which is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004815"
    },
    {
      "id": 6578,
      "label": "non-secretory plasma cell myeloma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        10907
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9547",
          "GARD:0024113",
          "MEDGEN:857719",
          "NCIT:C4734",
          "SCTID:277580004",
          "UMLS:C3898125"
        ],
        "synonyms": [
          "non-secretory multiple myeloma",
          "non-secretory plasma cell myeloma",
          "non-functioning myeloma",
          "non-secreting myeloma",
          "non-secretory myeloma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare type of multiple myeloma in which the plasma cells synthesize but do not secrete immunoglobulins. As a result, none of the immunoglobulins appear out of the normal range. The symptoms are generally the same with those of immunoglobulin-secreting myeloma; however, the incidence of renal insufficiency is lower in non-secretory myeloma. The diagnosis can be missed because of the absence of monoclonal immunoglobulin in the serum or urine."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004817"
    },
    {
      "id": 6945,
      "label": "smoldering plasma cell myeloma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        10907
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9551",
          "EFO:0003073",
          "GARD:0024168",
          "MEDGEN:280653",
          "NCIT:C7149",
          "SCTID:440422002",
          "UMLS:C1531608"
        ],
        "synonyms": [
          "asymptomatic myeloma",
          "asymptomatic plasma cell myeloma",
          "smoldering Multiple myeloma/plasma cell myeloma",
          "smoldering multiple myeloma",
          "smoldering myeloma",
          "smoldering plasma cell myeloma",
          "smouldering Multiple myeloma/plasma cell myeloma",
          "smouldering multiple myeloma",
          "smouldering myeloma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A plasma cell myeloma lacking clinical manifestations and organ impairment."
      },
      "child_count": 1,
      "reference_id": "MONDO:0005235"
    }
  ],
  "roots": [
    {
      "id": 3028,
      "label": "immune system cancer"
    },
    {
      "id": 6702,
      "label": "plasma cell neoplasm"
    },
    {
      "id": 6892,
      "label": "myeloid neoplasm"
    }
  ]
}