{
  "id": 11016,
  "label": "osteosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009807",
  "properties": {
    "xrefs": [
      "DOID:3347",
      "EFO:0000637",
      "HP:0002669",
      "ICDO:9180/3",
      "MEDGEN:10501",
      "MESH:D012516",
      "NANDO:2200048",
      "NCIT:C9145",
      "ONCOTREE:OS",
      "UMLS:C0029463"
    ],
    "synonyms": [
      "bone tissue neoplasm",
      "osteogenic sarcoma",
      "osteoid sarcoma",
      "osteosarcoma",
      "osteosarcoma (disease)",
      "osteosarcoma, malignant",
      "sarcoma of osteoid"
    ],
    "definition": "A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 6816,
      "label": "sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1115",
          "EFO:0000691",
          "ICD9:171",
          "ICD9:171.0",
          "ICD9:171.2",
          "ICD9:171.3",
          "ICD9:171.4",
          "ICD9:171.5",
          "ICD9:171.6",
          "ICD9:171.7",
          "ICD9:171.8",
          "ICD9:171.9",
          "ICDO:8800/3",
          "MEDGEN:224714",
          "MESH:D012509",
          "NCIT:C9118",
          "SCTID:424413001",
          "UMLS:C1261473"
        ],
        "synonyms": [
          "mesenchymal tumor, malignant",
          "sarcoma",
          "sarcoma of soft tissue and bone",
          "sarcoma of the soft tissue and bone",
          "sarcoma, malignant",
          "tumor of soft tissue and skeleton",
          "tumour of soft tissue and skeleton"
        ],
        "definition": "A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005089"
    }
  ],
  "children": [
    {
      "id": 4671,
      "label": "localized osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11016
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3356",
          "MEDGEN:124467",
          "NCIT:C7780",
          "UMLS:C0278511"
        ],
        "synonyms": [
          "localized osteogenic sarcoma",
          "localized osteosarcoma",
          "osteosarcoma, localised",
          "osteosarcoma, localized"
        ],
        "definition": "A non-disseminated osteosarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002620"
    },
    {
      "id": 4672,
      "label": "extraosseous osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11016,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3357",
          "GARD:0023192",
          "ICD9:170.9",
          "MEDGEN:163186",
          "NCIT:C8810",
          "SCTID:404077005",
          "UMLS:C0855052"
        ],
        "synonyms": [
          "extraosseous osteosarcoma",
          "extraskeletal osteogenic sarcoma",
          "extraskeletal osteosarcoma",
          "osteosarcoma, extraskeletal, malignant",
          "soft tissue osteosarcoma"
        ],
        "definition": "An osteosarcoma arising from the soft tissue."
      },
      "child_count": 14,
      "reference_id": "MONDO:0002621"
    },
    {
      "id": 4673,
      "label": "multifocal osteogenic sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11016
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3360",
          "MEDGEN:233199",
          "NCIT:C6470",
          "UMLS:C1334820"
        ],
        "synonyms": [
          "multicentric osteosarcoma",
          "multifocal osteosarcoma"
        ],
        "definition": "A primary bone osteosarcoma affecting multiple bone sites."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002622"
    },
    {
      "id": 4674,
      "label": "pediatric osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8005,
        11016
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3361",
          "MEDGEN:272464",
          "NANDO:2200048",
          "NCIT:C6585",
          "UMLS:C1332986"
        ],
        "synonyms": [
          "osteosarcoma",
          "childhood osteogenic sarcoma",
          "childhood osteosarcoma",
          "childhood osteosarcoma (disease)",
          "osteosarcoma (disease) of childhood",
          "paediatric osteosarcoma (disease)",
          "pediatric osteosarcoma",
          "pediatric osteosarcoma (disease)"
        ],
        "definition": "An osteosarcoma occurring in childhood."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002623"
    },
    {
      "id": 4680,
      "label": "bone osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11016,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3376",
          "GARD:0007284",
          "ICD9:170.9",
          "MEDGEN:108437",
          "MedDRA:10031291",
          "NCIT:C53707",
          "OMIM:259500",
          "Orphanet:668",
          "SCTID:307576001",
          "UMLS:C0585442"
        ],
        "synonyms": [
          "bone osteosarcoma",
          "osteosarcoma of bone",
          "osteosarcoma, somatic",
          "osteosarcoma, somatic mutation"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It may arise de novo or from a pre-existing lesion of the bone. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs."
      },
      "child_count": 10,
      "reference_id": "MONDO:0002629"
    },
    {
      "id": 7814,
      "label": "low grade central osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11016
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:9187/3",
          "MEDGEN:818980",
          "NCIT:C6474",
          "ONCOTREE:LGCOS",
          "UMLS:C3814534"
        ],
        "synonyms": [
          "intraosseous well-differentiated osteogenic sarcoma",
          "intraosseous well-differentiated osteosarcoma",
          "low grade central osteosarcoma",
          "low grade intramedullary osteosarcoma",
          "low-grade intramedullary osteosarcoma",
          "low-grade central osteosarcoma"
        ],
        "definition": "A low grade osteosarcoma arising from the medullary portion of the bone. It affects the long bones and is characterized by the presence of fibroblastic stroma and osteoid production. Pain and swelling are the usual sign and symptom. The prognosis is more favorable than conventional osteosarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006271"
    }
  ],
  "roots": [
    {
      "id": 6816,
      "label": "sarcoma"
    }
  ]
}